ID   GSM1_KOMPG              Reviewed;         531 AA.
AC   C4QV17;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Glucose starvation modulator protein 1;
GN   Name=GSM1; OrderedLocusNames=PAS_chr1-3_0036;
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864;
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; FN392319; CAY67087.1; -; Genomic_DNA.
DR   RefSeq; XP_002489371.1; XM_002489326.1.
DR   AlphaFoldDB; C4QV17; -.
DR   STRING; 644223.C4QV17; -.
DR   EnsemblFungi; CAY67087; CAY67087; PAS_chr1-3_0036.
DR   GeneID; 8197348; -.
DR   KEGG; ppa:PAS_chr1-3_0036; -.
DR   eggNOG; ENOG502R2ZP; Eukaryota.
DR   HOGENOM; CLU_010748_2_2_1; -.
DR   InParanoid; C4QV17; -.
DR   OMA; CHEKHLQ; -.
DR   Proteomes; UP000000314; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..531
FT                   /note="Glucose starvation modulator protein 1"
FT                   /id="PRO_0000406489"
FT   DOMAIN          411..483
FT                   /note="PAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DNA_BIND        20..48
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          56..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   531 AA;  60309 MW;  1C7A8432F20471B8 CRC64;
     MTKPLPLEVK RSRRPTSRAC KFCHFKHLQC DATRPCKNCV KRNIGDSCED IQRRKYGSNG
     TKKRAQSAQK VQSDSPSASS ATNAGTSAVN ESKLESSELP MVAQQTQQTP RGLETIPTIP
     HPNAENNSSF LSPTTSQMFN TGSNTLMDQL KMSVPENNSM YQHDTLFQPP KKYENNSYGY
     VNAAPQGQHM FYVGYSEPGE QRASPDAEKE PGTNLNSPSS YLSQYSHTQS HTNSQLTNSP
     SVVYESEIAK QEELQLTSFV EAANNEELDF FDMDFTQRPF IRLLENNTMV SSYPNNSTPK
     FFDHSRSHGR IPNTAKEVPT EIQQDEEFTP PLILRHIIKN PDDIYLTRVV KAYQYPKAYH
     ALTKYLKTRF ERTQLIEIAK CMSKYRPSFI SATKSLVEND LIFTERSFQR SLLEYESLIS
     MSAAPTIIWR RTGEIVALTN EFSVLTGYSR MSLLSKRTFI IELMDDESVV NYFKLFSSIA
     FGDLNATLLT NCVLRKAAQD DYLRCACVWT IKRDVFDIPM LIVGQFLPVL D