GSP1_CANAW
ID GSP1_CANAW Reviewed; 214 AA.
AC Q9P4E9; C4YIU6;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=GTP-binding nuclear protein GSP1/Ran;
GN Name=GSP1; ORFNames=CAWG_04375;
OS Candida albicans (strain WO-1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294748;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=WO-1;
RX PubMed=10854789; DOI=10.1016/s0378-1119(00)00173-6;
RA Clement M., Fournier H., de Repentigny L., Belhumeur P.;
RT "Characterization of CaGSP1, the Candida albicans Ran/GSP1 homolog.";
RL Gene 250:159-169(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-1;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport.
CC Required for the import of protein into the nucleus and also for RNA
CC export. Involved in chromatin condensation and control of cell cycle
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Found in a nuclear export complex with RanGTP, exportin and
CC pre-miRNA (By similarity). {ECO:0000250|UniProtKB:P62825}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC {ECO:0000305}.
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DR EMBL; AF190700; AAF78478.1; -; Genomic_DNA.
DR EMBL; CH672350; EEQ46031.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9P4E9; -.
DR SMR; Q9P4E9; -.
DR STRING; 5476.Q9P4E9; -.
DR PRIDE; Q9P4E9; -.
DR EnsemblFungi; EEQ46031; EEQ46031; CAWG_04375.
DR VEuPathDB; FungiDB:CAWG_04375; -.
DR HOGENOM; CLU_041217_13_0_1; -.
DR OMA; TIVFHRK; -.
DR Proteomes; UP000001429; Chromosome 2, Supercontig 1.5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002041; Ran_GTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR24071; PTHR24071; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00627; GTPRANTC4.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51418; RAN; 1.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Nucleus; Protein transport; Transport.
FT CHAIN 1..214
FT /note="GTP-binding nuclear protein GSP1/Ran"
FT /id="PRO_0000208729"
FT BINDING 15..22
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
FT BINDING 65
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
FT BINDING 119..122
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
FT BINDING 147..149
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
FT CONFLICT 45
FT /note="H -> N (in Ref. 1; AAF78478)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 214 AA; 24314 MW; 5A40AB9D9ED11520 CRC64;
MAQEVPTFKL VLVGDGGTGK TTFVKRHLTG EFEKKYIATL GVEVHPLGFH TNFGELKFDV
WDTAGQEKFG GLRDGYYING QCGIIMFDVT SRITYKNVPN WHRDLVRVCE NIPIVLCGNK
VDVKERKVKA KTITFHRKKN LQYYDISAKS NYNFEKPFLW LARKLVGNPQ LEFVASPALA
PPEVQVDADL MQKYQQEMEQ ATALPLPDED DADL
