GSPC_VIBCH
ID GSPC_VIBCH Reviewed; 305 AA.
AC P45777; Q9KNK4;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Type II secretion system protein C;
DE Short=T2SS protein C;
DE AltName: Full=Cholera toxin secretion protein EpsC;
DE AltName: Full=General secretion pathway protein C;
GN Name=epsC; OrderedLocusNames=VC_2734;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=El Tor TRH7000;
RA Overbye L.J.;
RT "Organization of the general secretion pathway genes in Vibrio cholerae.";
RL Thesis (1994), Michigan State University, United States.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- FUNCTION: Involved in a type II secretion system (T2SS, formerly
CC general secretion pathway, GSP) for the export of proteins (By
CC similarity). Required for secretion of cholera toxin through the outer
CC membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the GSP C family. {ECO:0000305}.
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DR EMBL; L33796; AAA58784.1; -; Genomic_DNA.
DR EMBL; AE003852; AAF95873.1; -; Genomic_DNA.
DR PIR; G82041; G82041.
DR RefSeq; NP_232360.1; NC_002505.1.
DR RefSeq; WP_000394676.1; NZ_LT906614.1.
DR PDB; 2I4S; X-ray; 1.92 A; A/B=204-305.
DR PDB; 2I6V; X-ray; 1.63 A; A=219-305.
DR PDBsum; 2I4S; -.
DR PDBsum; 2I6V; -.
DR AlphaFoldDB; P45777; -.
DR SMR; P45777; -.
DR STRING; 243277.VC_2734; -.
DR PRIDE; P45777; -.
DR DNASU; 2614897; -.
DR EnsemblBacteria; AAF95873; AAF95873; VC_2734.
DR GeneID; 57741326; -.
DR KEGG; vch:VC_2734; -.
DR PATRIC; fig|243277.26.peg.2610; -.
DR eggNOG; COG3031; Bacteria.
DR HOGENOM; CLU_068012_0_0_6; -.
DR OMA; WRIIPEP; -.
DR BioCyc; VCHO:VC2734-MON; -.
DR EvolutionaryTrace; P45777; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015627; C:type II protein secretion system complex; IEA:InterPro.
DR GO; GO:0015628; P:protein secretion by the type II secretion system; IEA:InterPro.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR024961; T2SS_GspC_N.
DR InterPro; IPR001639; T2SS_protein-GspC.
DR Pfam; PF11356; T2SSC; 1.
DR PRINTS; PR00810; BCTERIALGSPC.
DR SUPFAM; SSF50156; SSF50156; 1.
DR TIGRFAMs; TIGR01713; typeII_sec_gspC; 1.
DR PROSITE; PS01141; T2SP_C; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell inner membrane; Cell membrane; Membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..305
FT /note="Type II secretion system protein C"
FT /id="PRO_0000215005"
FT TOPO_DOM 1..29
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..305
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 44
FT /note="G -> A (in Ref. 1; AAA58784)"
FT /evidence="ECO:0000305"
FT HELIX 204..216
FT /evidence="ECO:0007829|PDB:2I4S"
FT HELIX 218..220
FT /evidence="ECO:0007829|PDB:2I4S"
FT HELIX 221..223
FT /evidence="ECO:0007829|PDB:2I6V"
FT STRAND 225..232
FT /evidence="ECO:0007829|PDB:2I6V"
FT STRAND 235..243
FT /evidence="ECO:0007829|PDB:2I6V"
FT HELIX 247..252
FT /evidence="ECO:0007829|PDB:2I6V"
FT STRAND 260..264
FT /evidence="ECO:0007829|PDB:2I6V"
FT HELIX 272..280
FT /evidence="ECO:0007829|PDB:2I6V"
FT HELIX 281..284
FT /evidence="ECO:0007829|PDB:2I6V"
FT STRAND 286..294
FT /evidence="ECO:0007829|PDB:2I6V"
FT STRAND 297..304
FT /evidence="ECO:0007829|PDB:2I6V"
SQ SEQUENCE 305 AA; 33585 MW; 9D760097CDEF7066 CRC64;
MEFKQLPPLA AWPRLLSQNT LRWQKPISEG LTLLLLVASA WTLGKMVWVV SAEQTPVPTW
SPTLSGLKAE RQPLDISVLQ KGELFGVFTE PKEAPVVEQP VVVDAPKTRL SLVLSGVVAS
NDAQKSLAVI ANRGVQATYG INEVIEGTQA KLKAVMPDRV IISNSGRDET LMLEGLDYTA
PATASVSNPP RPRPNQPNAV PQFEDKVDAI REAIARNPQE IFQYVRLSQV KRDDKVLGYR
VSPGKDPVLF ESIGLQDGDM AVALNGLDLT DPNVMNTLFQ SMNEMTEMSL TVERDGQQHD
VYIQF
