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GSPF_KLEPN
ID   GSPF_KLEPN              Reviewed;         381 AA.
AC   P15745;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Type II secretion system protein F;
DE            Short=T2SS protein F;
DE   AltName: Full=General secretion pathway protein F;
DE   AltName: Full=Pullulanase secretion protein PulF;
GN   Name=pulF;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Pugsley A.P., D'Enfert C., Reyss I., Wandersman C.;
RL   Submitted (MAR-1990) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=1738317; DOI=10.1111/j.1365-2958.1992.tb00841.x;
RA   Possot O., d'Enfert C., Reyss I., Pugsley A.P.;
RT   "Pullulanase secretion in Escherichia coli K-12 requires a cytoplasmic
RT   protein and a putative polytopic cytoplasmic membrane protein.";
RL   Mol. Microbiol. 6:95-105(1992).
CC   -!- FUNCTION: Component of the type II secretion system inner membrane
CC       complex required for the energy-dependent secretion of extracellular
CC       factors such as proteases and toxins from the periplasm.
CC       {ECO:0000250|UniProtKB:Q00514}.
CC   -!- SUBUNIT: Type II secretion system is composed of four main components:
CC       the outer membrane complex, the inner membrane complex, the cytoplasmic
CC       secretion ATPase and the periplasm-spanning pseudopilus (By
CC       similarity). Homodimer (By similarity). Interacts with PulE and PulL
CC       components (By similarity). {ECO:0000250|UniProtKB:P45780,
CC       ECO:0000250|UniProtKB:Q00513, ECO:0000250|UniProtKB:Q00514}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GSP F family. {ECO:0000305}.
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DR   EMBL; M32613; AAA25128.1; -; Genomic_DNA.
DR   PIR; S20035; S20035.
DR   AlphaFoldDB; P15745; -.
DR   SMR; P15745; -.
DR   TCDB; 3.A.15.1.1; the outer membrane protein secreting main terminal branch (mtb) family.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 1.20.81.30; -; 2.
DR   InterPro; IPR003004; GspF/PilC.
DR   InterPro; IPR001992; T2SS_GspF/T4SS_PilC_CS.
DR   InterPro; IPR018076; T2SS_GspF_dom.
DR   InterPro; IPR042094; T2SS_GspF_sf.
DR   PANTHER; PTHR30012; PTHR30012; 2.
DR   Pfam; PF00482; T2SSF; 2.
DR   PRINTS; PR00812; BCTERIALGSPF.
DR   PROSITE; PS00874; T2SP_F; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..381
FT                   /note="Type II secretion system protein F"
FT                   /id="PRO_0000207834"
FT   TOPO_DOM        1..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q00513"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..197
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q00513"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..352
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q00513"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        374..381
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P41441"
SQ   SEQUENCE   381 AA;  41873 MW;  01347C0994B29933 CRC64;
     MALFRYQALD EQGKPRRGVQ QADSARHARQ LLREKGWLAL DIDPAAGGGR PSRFMRRTSA
     RDLALVTRQL ATLVAAAIPL EKALDAVAQQ SEKPQLKTLI AGVRGKVLEG HSLAEAMRGH
     PGCFDALYCA MVAAGEASGH RLLQAMIYPI VLTLVAVSVI VILLSTVVPK VVEQFIHLKQ
     ALPFSTRLLM AMSDMLRAAG PWLLLAILLL ILLLRYLLRQ PAKRLAWHRL LLRLPLIGRV
     ARSVNSARYA RTLSILNASA VPLLLAMRIS ADVLSNAWAK RQLEAASDAV REGVSLHRAL
     EMTQLFPPMM RYMVASGERS GELNSMLERA ADNQDRDLSA QIQLALSLFE PLLVVAMAGM
     VLFIVLAILQ PILQLNTLMS M
 
 
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