ID   GSPM_AERHY              Reviewed;         163 AA.
AC   P41850;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Type II secretion system protein M;
DE            Short=T2SS protein M;
DE   AltName: Full=General secretion pathway protein M;
GN   Name=exeM;
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ah65;
RX   PubMed=8407845; DOI=10.1128/jb.175.20.6695-6703.1993;
RA   Howard S.P., Critch J., Bedi A.;
RT   "Isolation and analysis of eight exe genes and their involvement in
RT   extracellular protein secretion and outer membrane assembly in Aeromonas
RT   hydrophila.";
RL   J. Bacteriol. 175:6695-6703(1993).
CC   -!- FUNCTION: Inner membrane component of the type II secretion system
CC       required for the energy-dependent secretion of extracellular factors
CC       such as proteases and toxins from the periplasm. Plays a role in the
CC       complex assembly and recruits ExeL resulting in a stable complex in the
CC       inner membrane. Provides thus a link between the energy-providing ExeE
CC       protein in the cytoplasm and the rest of the T2SS machinery.
CC       {ECO:0000250|UniProtKB:P25061}.
CC   -!- SUBUNIT: Type II secretion system is composed of four main components:
CC       the outer membrane complex, the inner membrane complex, the cytoplasmic
CC       secretion ATPase and the periplasm-spanning pseudopilus (By
CC       similarity). Forms homodimers (By similarity). Interacts with
CC       ExeL/GspL. Interacts with ExeE/GspE and ExeF/GspF (By similarity).
CC       {ECO:0000250|UniProtKB:P25061, ECO:0000250|UniProtKB:P41851,
CC       ECO:0000250|UniProtKB:Q00514}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P25061}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P25061}.
CC   -!- SIMILARITY: Belongs to the GSP M family. {ECO:0000305}.
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DR   EMBL; X66504; CAA47134.1; -; Genomic_DNA.
DR   PIR; F49905; F49905.
DR   AlphaFoldDB; P41850; -.
DR   SMR; P41850; -.
DR   STRING; 1448139.AI20_16485; -.
DR   eggNOG; COG3149; Bacteria.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015627; C:type II protein secretion system complex; IEA:InterPro.
DR   GO; GO:0015628; P:protein secretion by the type II secretion system; IEA:InterPro.
DR   InterPro; IPR007690; T2SS_GspM.
DR   InterPro; IPR023229; T2SS_M_periplasmic_sf.
DR   Pfam; PF04612; T2SSM; 1.
DR   PIRSF; PIRSF006291; GspM; 1.
DR   SUPFAM; SSF103054; SSF103054; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..163
FT                   /note="Type II secretion system protein M"
FT                   /id="PRO_0000207322"
FT   TOPO_DOM        1..19
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P25061"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..163
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P25061"
SQ   SEQUENCE   163 AA;  18571 MW;  3D3428347E081436 CRC64;
     MMDKLQGWWR SISAREQRLV AVGGSCLLIG FCYWIVWQPI ANRIAERERQ VLSQQQTLAW
     LKEKGEEVLA MQGGQGRQID TSGTLEGVVN RTAFNQKIKI ARLQPQGQEL QVWIDTVQFD
     DLLIWLASLA DQHGVQVQVI EVARENLAPG LVKVRRLQLS RPQ