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GSPM_DICCH
ID   GSPM_DICCH              Reviewed;         161 AA.
AC   Q47422;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   07-OCT-2020, entry version 79.
DE   RecName: Full=Type II secretion system protein M;
DE            Short=T2SS protein M;
DE   AltName: Full=General secretion pathway protein M;
DE   AltName: Full=Pectic enzymes secretion protein OutM;
GN   Name=outM;
OS   Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Dickeya.
OX   NCBI_TaxID=556;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=EC16;
RX   PubMed=1429461; DOI=10.1128/jb.174.22.7385-7397.1992;
RA   Lindeberg M., Collmer A.;
RT   "Analysis of eight out genes in a cluster required for pectic enzyme
RT   secretion by Erwinia chrysanthemi: sequence comparison with secretion genes
RT   from other Gram-negative bacteria.";
RL   J. Bacteriol. 174:7385-7397(1992).
RN   [2]
RP   INTERACTION WITH OUTL/GSPL, AND FUNCTION.
RX   PubMed=11266368; DOI=10.1093/embo-reports/kve042;
RA   Py B., Loiseau L., Barras F.;
RT   "An inner membrane platform in the type II secretion machinery of Gram-
RT   negative bacteria.";
RL   EMBO Rep. 2:244-248(2001).
CC   -!- FUNCTION: Inner membrane component of the type II secretion system
CC       required for the energy-dependent secretion of extracellular factors
CC       such as proteases and toxins from the periplasm. Plays a role in the
CC       complex assembly and recruits OutL resulting in a stable complex in the
CC       inner membrane (By similarity). Provides thus a link between the
CC       energy-providing OutE protein in the cytoplasm and the rest of the T2SS
CC       machinery (PubMed:11266368). {ECO:0000250|UniProtKB:P25061,
CC       ECO:0000269|PubMed:11266368}.
CC   -!- SUBUNIT: Type II secretion system is composed of four main components:
CC       the outer membrane complex, the inner membrane complex, the cytoplasmic
CC       secretion ATPase and the periplasm-spanning pseudopilus (By
CC       similarity). Forms homodimers (By similarity). Interacts with OutL/GspL
CC       (PubMed:11266368). Interacts with OutE/GspE and OutF/GspF (By
CC       similarity). {ECO:0000250|UniProtKB:P25061,
CC       ECO:0000250|UniProtKB:P41851, ECO:0000250|UniProtKB:Q00514,
CC       ECO:0000269|PubMed:11266368}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P25061}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P25061}.
CC   -!- SIMILARITY: Belongs to the GSP M family. {ECO:0000305}.
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DR   EMBL; L02214; AAA24840.1; -; Genomic_DNA.
DR   PIR; B47755; B47755.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015627; C:type II protein secretion system complex; IEA:InterPro.
DR   GO; GO:0015628; P:protein secretion by the type II secretion system; IEA:InterPro.
DR   InterPro; IPR007690; T2SS_GspM.
DR   InterPro; IPR023229; T2SS_M_periplasmic_sf.
DR   Pfam; PF04612; T2SSM; 1.
DR   PIRSF; PIRSF006291; GspM; 1.
DR   SUPFAM; SSF103054; SSF103054; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..161
FT                   /note="Type II secretion system protein M"
FT                   /id="PRO_0000207325"
FT   TOPO_DOM        1..16
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P25061"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..161
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P25061"
SQ   SEQUENCE   161 AA;  18622 MW;  DDEDD3C69345D920 CRC64;
     MNELRRRWQV MSQRERLMAL ACGGLVVLCL LYYLIWAPWQ ESVRQWQMTV ERERQTVRWM
     QQQPPRFRRR KVRGGRXPVA ISANGIGAQS AVRYGITVLR MQPQESQVSV TLARSDFNNL
     LHWLAELEQK NGVITQGIDV TAVPNSPGIV EVTRLSLERV L
 
 
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