GSPN_PSEAE
ID GSPN_PSEAE Reviewed; 235 AA.
AC Q51575; Q9HZB3;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Type II secretion system protein N;
DE Short=T2SS protein N;
DE AltName: Full=General secretion pathway protein N;
DE AltName: Full=Protein XcpP;
GN Name=xcpP; OrderedLocusNames=PA3104;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=7934833; DOI=10.1111/j.1365-2958.1993.tb02674.x;
RA Akrim M., Bally M., Ball G., Tommassen J., Teerink H., Filloux A.,
RA Lazdunski A.;
RT "Xcp-mediated protein secretion in Pseudomonas aeruginosa: identification
RT of two additional genes and evidence for regulation of xcp gene
RT expression.";
RL Mol. Microbiol. 10:431-443(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [3]
RP SUBCELLULAR LOCATION, AND TOPOLOGY.
RX PubMed=8763961; DOI=10.1128/jb.178.14.4297-4300.1996;
RA Bleves S., Lazdunski A., Filloux A.;
RT "Membrane topology of three Xcp proteins involved in exoprotein transport
RT by Pseudomonas aeruginosa.";
RL J. Bacteriol. 178:4297-4300(1996).
CC -!- FUNCTION: Involved in a type II secretion system (T2SS, formerly
CC general secretion pathway, GSP) for the export of proteins (By
CC similarity). Required for the translocation of a variety of enzymes
CC across the outer membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:8763961};
CC Single-pass type II membrane protein {ECO:0000269|PubMed:8763961}.
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DR EMBL; X68594; CAA48581.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG06492.1; -; Genomic_DNA.
DR PIR; S39652; S39652.
DR RefSeq; NP_251794.1; NC_002516.2.
DR RefSeq; WP_003119750.1; NZ_QZGE01000009.1.
DR AlphaFoldDB; Q51575; -.
DR STRING; 287.DR97_4829; -.
DR PaxDb; Q51575; -.
DR PRIDE; Q51575; -.
DR DNASU; 877805; -.
DR EnsemblBacteria; AAG06492; AAG06492; PA3104.
DR GeneID; 877805; -.
DR KEGG; pae:PA3104; -.
DR PATRIC; fig|208964.12.peg.3256; -.
DR PseudoCAP; PA3104; -.
DR HOGENOM; CLU_1306166_0_0_6; -.
DR InParanoid; Q51575; -.
DR OMA; QDEVPYA; -.
DR BioCyc; PAER208964:G1FZ6-3160-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015627; C:type II protein secretion system complex; IDA:PseudoCAP.
DR GO; GO:0015628; P:protein secretion by the type II secretion system; IDA:PseudoCAP.
DR InterPro; IPR024961; T2SS_GspC_N.
DR Pfam; PF11356; T2SSC; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..235
FT /note="Type II secretion system protein N"
FT /id="PRO_0000195055"
FT TOPO_DOM 1..34
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..235
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT REGION 205..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 235 AA; 25497 MW; DE9726984D89A0D7 CRC64;
MIPRRSSDIT IKTRSDVLPF SGASSRWLQR YAPALLAVAL IIAMSISLAW QAAGWLRLQR
SPVAVAASPV SHESIRSDPT RLARLFGTSA QDPNAPPPAT NLDLVLKGSF VQSDPKLSSA
IIQRQGDKPH RYAVGGEISD GVKLHAVYRD RVELQRGGRL ESLPFPHRSG GLLASADDIT
SENDSIEQLQ SLQDENAAAL RERLDALRQQ MEATPIAEPA EEDSSEPTTT PTESD
