ID   GST2_SCHPO              Reviewed;         230 AA.
AC   O59827;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 137.
DE   RecName: Full=Glutathione S-transferase 2;
DE            EC=2.5.1.18;
DE   AltName: Full=GST-II;
GN   Name=gst2; ORFNames=SPCC965.07c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RX   PubMed=11997110; DOI=10.1016/s0167-4781(01)00363-3;
RA   Cho Y.-W., Park E.-H., Fuchs J.A., Lim C.-J.;
RT   "A second stress-inducible glutathione S-transferase gene from
RT   Schizosaccharomyces pombe.";
RL   Biochim. Biophys. Acta 1574:399-402(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Involved in the oxidative stress response and detoxification.
CC       {ECO:0000269|PubMed:11997110}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glutathione + RX = a halide anion + an S-substituted
CC         glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC         ChEBI:CHEBI:90779; EC=2.5.1.18;
CC   -!- INDUCTION: By O-dinitrobenzene. {ECO:0000269|PubMed:11997110}.
CC   -!- SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}.
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DR   EMBL; AF395117; AAK77864.1; -; Genomic_DNA.
DR   EMBL; CU329672; CAA19067.1; -; Genomic_DNA.
DR   PIR; T41660; T41660.
DR   RefSeq; NP_588517.1; NM_001023506.2.
DR   AlphaFoldDB; O59827; -.
DR   SMR; O59827; -.
DR   BioGRID; 276159; 3.
DR   STRING; 4896.SPCC965.07c.1; -.
DR   MaxQB; O59827; -.
DR   PaxDb; O59827; -.
DR   EnsemblFungi; SPCC965.07c.1; SPCC965.07c.1:pep; SPCC965.07c.
DR   GeneID; 2539601; -.
DR   KEGG; spo:SPCC965.07c; -.
DR   PomBase; SPCC965.07c; gst2.
DR   VEuPathDB; FungiDB:SPCC965.07c; -.
DR   eggNOG; KOG0867; Eukaryota.
DR   HOGENOM; CLU_011226_14_2_1; -.
DR   InParanoid; O59827; -.
DR   OMA; LSWLMFI; -.
DR   PhylomeDB; O59827; -.
DR   PRO; PR:O59827; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; IDA:PomBase.
DR   GO; GO:0004364; F:glutathione transferase activity; IMP:PomBase.
DR   GO; GO:1990748; P:cellular detoxification; NAS:PomBase.
DR   GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Transferase.
FT   CHAIN           1..230
FT                   /note="Glutathione S-transferase 2"
FT                   /id="PRO_0000185985"
FT   DOMAIN          2..86
FT                   /note="GST N-terminal"
FT   DOMAIN          93..230
FT                   /note="GST C-terminal"
SQ   SEQUENCE   230 AA;  26843 MW;  5B96437DD51CCB2A CRC64;
     MAHFTLYSHA GGPNPWKVVL ALKELNLSYE QIFYDFQKGE QKCKEHLALN PNGRVPTLVD
     HKNNDYTIWE SDAILIYLAD KYDTDRKISL SFDDPEYYKL IQYLFFQASG QGVIWGQAGW
     FNFFHHEPVV SAVTRYRNEI KRVLGVLEDI LKDRDYLVAN KYTIADLSFI PWNYNLGGLF
     GEGKFSFKEE VPQLDFEKEF PKAYAWNQRL LARPAVKATF EELAKAKEQH