GST82_DICLA
ID GST82_DICLA Reviewed; 32 AA.
AC P82608;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 40.
DE RecName: Full=Glutathione S-transferase 8.2;
DE Short=GST-8.2;
DE EC=2.5.1.18;
DE AltName: Full=GST class-alpha;
DE Flags: Fragments;
OS Dicentrarchus labrax (European seabass) (Morone labrax).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Moronidae; Dicentrarchus.
OX NCBI_TaxID=13489;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Liver;
RX PubMed=10620369; DOI=10.1006/abbi.1999.1569;
RA Angelucci S., Sacchetta P., Moio P., Melino S., Petruzzelli R., Gervasi P.,
RA Di Ilio C.;
RT "Purification and characterization of glutathione transferases from the sea
RT bass (Dicentrarchus labrax) liver.";
RL Arch. Biochem. Biophys. 373:435-441(2000).
CC -!- FUNCTION: Conjugation of reduced glutathione to a wide number of
CC exogenous and endogenous hydrophobic electrophiles.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC -!- SUBUNIT: Homodimer.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- PTM: The N-terminus is blocked.
CC -!- SIMILARITY: Belongs to the GST superfamily. Alpha family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Proteomes; UP000694389; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004364; F:glutathione transferase activity; IEA:UniProtKB-EC.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Reference proteome; Transferase.
FT CHAIN <1..>32
FT /note="Glutathione S-transferase 8.2"
FT /id="PRO_0000185804"
FT BINDING 21..22
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250|UniProtKB:P13745"
FT NON_CONS 16..17
FT /evidence="ECO:0000305"
FT NON_TER 1
FT NON_TER 32
SQ SEQUENCE 32 AA; 3743 MW; 806C6F142ED3C3EA CRC64;
MESIRWLLTV AQFDFDMKLV QSXAIVNYVA NK