GSTCD_HUMAN
ID GSTCD_HUMAN Reviewed; 633 AA.
AC Q8NEC7; A8K8J0; A8MVD3; H9KV97; Q9H8S3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Glutathione S-transferase C-terminal domain-containing protein;
GN Name=GSTCD;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Ovary, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterine endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [6]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=24058608; DOI=10.1371/journal.pone.0074630;
RA Obeidat M., Miller S., Probert K., Billington C.K., Henry A.P., Hodge E.,
RA Nelson C.P., Stewart C.E., Swan C., Wain L.V., Artigas M.S., Melen E.,
RA Ushey K., Hao K., Lamontagne M., Bosse Y., Postma D.S., Tobin M.D.,
RA Sayers I., Hall I.P.;
RT "GSTCD and INTS12 regulation and expression in the human lung.";
RL PLoS ONE 8:E74630-E74630(2013).
CC -!- INTERACTION:
CC Q8NEC7; O60341: KDM1A; NbExp=2; IntAct=EBI-8469616, EBI-710124;
CC Q8NEC7; Q96LA8: PRMT6; NbExp=2; IntAct=EBI-8469616, EBI-912440;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24058608}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NEC7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NEC7-3; Sequence=VSP_045228;
CC -!- TISSUE SPECIFICITY: Widely expressed in cell types relevant to airway
CC function, including airway smooth muscle cells and epithelial cells.
CC {ECO:0000269|PubMed:24058608}.
CC -!- SIMILARITY: Belongs to the GSTCD family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14532.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BX648355; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK023335; BAB14532.1; ALT_SEQ; mRNA.
DR EMBL; AK292355; BAF85044.1; -; mRNA.
DR EMBL; BX648355; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC008243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC105391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032942; AAH32942.1; -; mRNA.
DR CCDS; CCDS3672.2; -. [Q8NEC7-3]
DR CCDS; CCDS43257.1; -. [Q8NEC7-1]
DR RefSeq; NP_001026890.2; NM_001031720.3. [Q8NEC7-1]
DR RefSeq; NP_079027.2; NM_024751.3. [Q8NEC7-3]
DR RefSeq; XP_005263279.1; XM_005263222.3.
DR RefSeq; XP_011530550.1; XM_011532248.2. [Q8NEC7-1]
DR RefSeq; XP_011530551.1; XM_011532249.2. [Q8NEC7-1]
DR RefSeq; XP_011530554.1; XM_011532252.2. [Q8NEC7-1]
DR AlphaFoldDB; Q8NEC7; -.
DR BioGRID; 122903; 23.
DR IntAct; Q8NEC7; 14.
DR MINT; Q8NEC7; -.
DR STRING; 9606.ENSP00000422354; -.
DR iPTMnet; Q8NEC7; -.
DR PhosphoSitePlus; Q8NEC7; -.
DR BioMuta; GSTCD; -.
DR DMDM; 167008865; -.
DR EPD; Q8NEC7; -.
DR jPOST; Q8NEC7; -.
DR MassIVE; Q8NEC7; -.
DR MaxQB; Q8NEC7; -.
DR PaxDb; Q8NEC7; -.
DR PeptideAtlas; Q8NEC7; -.
DR PRIDE; Q8NEC7; -.
DR ProteomicsDB; 46244; -.
DR ProteomicsDB; 73150; -. [Q8NEC7-1]
DR Antibodypedia; 26176; 97 antibodies from 21 providers.
DR DNASU; 79807; -.
DR Ensembl; ENST00000360505.9; ENSP00000353695.5; ENSG00000138780.15. [Q8NEC7-1]
DR Ensembl; ENST00000394728.4; ENSP00000378216.3; ENSG00000138780.15. [Q8NEC7-1]
DR Ensembl; ENST00000394730.7; ENSP00000378218.3; ENSG00000138780.15. [Q8NEC7-3]
DR Ensembl; ENST00000515279.6; ENSP00000422354.1; ENSG00000138780.15. [Q8NEC7-1]
DR GeneID; 79807; -.
DR KEGG; hsa:79807; -.
DR MANE-Select; ENST00000515279.6; ENSP00000422354.1; NM_001370181.1; NP_001357110.1.
DR UCSC; uc003hxy.4; human. [Q8NEC7-1]
DR CTD; 79807; -.
DR DisGeNET; 79807; -.
DR GeneCards; GSTCD; -.
DR HGNC; HGNC:25806; GSTCD.
DR HPA; ENSG00000138780; Low tissue specificity.
DR MIM; 615912; gene.
DR neXtProt; NX_Q8NEC7; -.
DR OpenTargets; ENSG00000138780; -.
DR PharmGKB; PA144596427; -.
DR VEuPathDB; HostDB:ENSG00000138780; -.
DR eggNOG; ENOG502QUFE; Eukaryota.
DR GeneTree; ENSGT00390000004446; -.
DR HOGENOM; CLU_013673_1_0_1; -.
DR InParanoid; Q8NEC7; -.
DR OMA; PRNRIYT; -.
DR OrthoDB; 911228at2759; -.
DR PhylomeDB; Q8NEC7; -.
DR TreeFam; TF324238; -.
DR PathwayCommons; Q8NEC7; -.
DR SignaLink; Q8NEC7; -.
DR BioGRID-ORCS; 79807; 16 hits in 1076 CRISPR screens.
DR ChiTaRS; GSTCD; human.
DR GenomeRNAi; 79807; -.
DR Pharos; Q8NEC7; Tbio.
DR PRO; PR:Q8NEC7; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8NEC7; protein.
DR Bgee; ENSG00000138780; Expressed in sperm and 160 other tissues.
DR ExpressionAtlas; Q8NEC7; baseline and differential.
DR Genevisible; Q8NEC7; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF13679; Methyltransf_32; 1.
DR SUPFAM; SSF47616; SSF47616; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR PROSITE; PS50405; GST_CTER; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..633
FT /note="Glutathione S-transferase C-terminal domain-
FT containing protein"
FT /id="PRO_0000316952"
FT DOMAIN 130..332
FT /note="GST C-terminal"
FT REGION 191..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 233
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 55..141
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_045228"
FT CONFLICT 10
FT /note="E -> G (in Ref. 1; BAF85044)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="Q -> R (in Ref. 1; BAB14532)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="Missing (in Ref. 4; AAH32942)"
FT /evidence="ECO:0000305"
FT CONFLICT 415
FT /note="K -> R (in Ref. 1; BAF85044)"
FT /evidence="ECO:0000305"
FT CONFLICT 474
FT /note="K -> R (in Ref. 2; BX648355)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 633 AA; 71079 MW; 709B8EA78BF0E732 CRC64;
MKAIKKSLTE EEYLYLDFSH QTEGCIFPLH TSVTLFLLSY CDCKIFKICL VVTKEVSRDS
SLLRDDLIQD VEIQIISRQE LPPIVQNCCL PAVVERSDNF CRAGLAVVLR HIIQKSYEAD
PLKKELLELL GFKKTCLKAC AEVSQWTRLC ELTIPLAIEN FLRESSDQPP TIPVEILQLE
KKLSEPVRVH NDDKLRRQKL KQQKADGVGP PLTKGKAKSK VHTQETSEGL DSSSKSLELK
VAFSKLTVQE EPATTNREPS HIRKAKASDL PPLEHVFAEG LYFTLADIVL LPCIHHFLVI
ISRKFSEKLV EFPLLASWYQ RIQEVPGVKT AASKCGIQFL HLPKLLTTST EQHPNLCEVP
GVEEQSDPLF IGGPRPTMAK LMEKGIEVMF SPHPCPTWTL DWNVLPAAVS PKEGKMSSDR
ALRKQQQLNN LVYVVTNQAK PGDRIVDFCS GGGHVGIVLA HMLPSCQVTL IENKELSLIR
AKKRSDELGL SNIWFIQANM EYFTGMFNIG VALHACGVAT DMVIEHCIKT RASFVTCPCC
YGFIQNTSKF NFPKSEQFKK TLSYKEHMIL CRFADQTAVQ LPPQRRLIGK QCMCLVDLDR
ARAAEECGYS VQVISMEPES CSPKNNMIVG VPI
