GSTCD_MOUSE
ID GSTCD_MOUSE Reviewed; 634 AA.
AC Q5RL51; Q6P8I1; Q8BXR2; Q8BYY6; Q9CTV2; Q9CUA9; Q9CXU7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Glutathione S-transferase C-terminal domain-containing protein;
GN Name=Gstcd;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-634 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Head, Retina, Skin, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Olfactory epithelium, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8NEC7}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q5RL51-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5RL51-2; Sequence=VSP_030826, VSP_030827;
CC Name=3;
CC IsoId=Q5RL51-3; Sequence=VSP_030823;
CC Name=4;
CC IsoId=Q5RL51-4; Sequence=VSP_030824, VSP_030825;
CC -!- SIMILARITY: Belongs to the GSTCD family. {ECO:0000305}.
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DR EMBL; AK037169; BAC29731.1; -; mRNA.
DR EMBL; AK013967; BAB29091.1; -; mRNA.
DR EMBL; AK017059; BAB30574.2; -; mRNA.
DR EMBL; AK020021; BAB31969.1; -; mRNA.
DR EMBL; AK044441; BAC31921.1; -; mRNA.
DR EMBL; BC047136; AAH47136.1; -; mRNA.
DR EMBL; BC061240; AAH61240.1; -; mRNA.
DR CCDS; CCDS17847.1; -. [Q5RL51-1]
DR RefSeq; NP_080507.2; NM_026231.2. [Q5RL51-1]
DR RefSeq; XP_006502001.1; XM_006501938.3.
DR AlphaFoldDB; Q5RL51; -.
DR IntAct; Q5RL51; 1.
DR MINT; Q5RL51; -.
DR STRING; 10090.ENSMUSP00000029651; -.
DR PhosphoSitePlus; Q5RL51; -.
DR EPD; Q5RL51; -.
DR MaxQB; Q5RL51; -.
DR PaxDb; Q5RL51; -.
DR PeptideAtlas; Q5RL51; -.
DR PRIDE; Q5RL51; -.
DR ProteomicsDB; 271476; -. [Q5RL51-1]
DR ProteomicsDB; 271477; -. [Q5RL51-2]
DR ProteomicsDB; 271478; -. [Q5RL51-3]
DR ProteomicsDB; 271479; -. [Q5RL51-4]
DR Antibodypedia; 26176; 97 antibodies from 21 providers.
DR DNASU; 67553; -.
DR Ensembl; ENSMUST00000029651; ENSMUSP00000029651; ENSMUSG00000028018. [Q5RL51-1]
DR Ensembl; ENSMUST00000080583; ENSMUSP00000079421; ENSMUSG00000028018. [Q5RL51-1]
DR GeneID; 67553; -.
DR KEGG; mmu:67553; -.
DR UCSC; uc008rkg.1; mouse. [Q5RL51-1]
DR UCSC; uc008rki.1; mouse. [Q5RL51-4]
DR UCSC; uc012cxx.1; mouse. [Q5RL51-2]
DR CTD; 79807; -.
DR MGI; MGI:1914803; Gstcd.
DR VEuPathDB; HostDB:ENSMUSG00000028018; -.
DR eggNOG; ENOG502QUFE; Eukaryota.
DR GeneTree; ENSGT00390000004446; -.
DR HOGENOM; CLU_013673_1_0_1; -.
DR InParanoid; Q5RL51; -.
DR OMA; PRNRIYT; -.
DR OrthoDB; 911228at2759; -.
DR PhylomeDB; Q5RL51; -.
DR TreeFam; TF324238; -.
DR BioGRID-ORCS; 67553; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Gstcd; mouse.
DR PRO; PR:Q5RL51; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q5RL51; protein.
DR Bgee; ENSMUSG00000028018; Expressed in manus and 202 other tissues.
DR Genevisible; Q5RL51; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF14497; GST_C_3; 1.
DR Pfam; PF13679; Methyltransf_32; 1.
DR SUPFAM; SSF47616; SSF47616; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR PROSITE; PS50405; GST_CTER; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Reference proteome.
FT CHAIN 1..634
FT /note="Glutathione S-transferase C-terminal domain-
FT containing protein"
FT /id="PRO_0000316954"
FT DOMAIN 131..333
FT /note="GST C-terminal"
FT REGION 189..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..378
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030823"
FT VAR_SEQ 301..330
FT /note="IICKKFSEKLEQFPLLTSWYQRIQEVPKVK -> RMCLQSSCYYAFQFDKLL
FT GFVFGSQQISCL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030824"
FT VAR_SEQ 331..634
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030825"
FT VAR_SEQ 512..542
FT /note="VALHACGVATDMVIEHCIQTRASFITCPCCY -> PNRPTTDVQCRDDKMFE
FT RAVMCDTVLTFSPH (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030826"
FT VAR_SEQ 543..634
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030827"
FT CONFLICT 198
FT /note="R -> I (in Ref. 2; AAH61240)"
FT /evidence="ECO:0000305"
FT CONFLICT 414
FT /note="E -> G (in Ref. 1; BAB29091)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 634 AA; 70618 MW; A895253353135EE8 CRC64;
MKGIKKSPTE ESLYLEYSHQ TEGCIFPLHT SVTLFLLSYC ECKVFNVCLV LTEESTDTSD
TSFLKEALPQ DLEIQVISKQ ALPPIVQNCC LPAVVDQPDV FCRAGLAVVL RHIIQKSYEA
EPSRKEILEL LGFKKTCLKA CAEVSQWTRL CELTIPLAVE NFLQESSEHP PTIPEEILEL
ERKLSEPVRV HNDDKLRRQK LKQQKAAGSE PPSGKGKAKS KASAQKTPKD LAAPSKSLEL
KVAFSKLTVQ EDAAASNREP SHIRKAKAAD LPPLEHVFAE GLYFTLADIV LLPCIHHFLV
IICKKFSEKL EQFPLLTSWY QRIQEVPKVK TAASKCGIYF LYLPELLNSA RKQPVNSDEV
AAVDEQSDPL FIGGPRPTMT KLMEKGIEAM FSPHPCPAWT LDWSSLPAAV SPKEGKMSTD
RALRKQQQLN NLVYLVLNQA KPGDRIVDFC SGGGHVGIVL AHMLPSCQVT LIENKELSLI
RAKKRSDELG LSNIWFIQAN MEYFTGMFNI GVALHACGVA TDMVIEHCIQ TRASFITCPC
CYGFIQNTSK FNFPKSEKFK KTLSYKEHML LCRFADQTAV QLPPERRLIG KQCMGLVDLD
RAAAAGEHGY SVQVISMEPE SCSPKNNMIV GVPL
