GSTF2_WHEAT
ID GSTF2_WHEAT Reviewed; 291 AA.
AC P30111;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Glutathione S-transferase 2;
DE EC=2.5.1.18;
DE AltName: Full=GST class-phi;
GN Name=GSTA2;
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Cheyenne;
RX PubMed=1650615; DOI=10.1007/bf00016083;
RA Mauch F., Hertig C., Rebmann G., Bull J., Dudler R.;
RT "A wheat glutathione-S-transferase gene with transposon-like sequences in
RT the promoter region.";
RL Plant Mol. Biol. 16:1089-1091(1991).
CC -!- FUNCTION: Conjugation of reduced glutathione to a wide number of
CC exogenous and endogenous hydrophobic electrophiles.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC -!- MISCELLANEOUS: GSTA2 is said to be a defective gene.
CC -!- SIMILARITY: Belongs to the GST superfamily. Phi family. {ECO:0000305}.
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DR EMBL; X56004; CAA39480.1; -; Genomic_DNA.
DR PIR; T06510; T06510.
DR AlphaFoldDB; P30111; -.
DR SMR; P30111; -.
DR PRIDE; P30111; -.
DR EnsemblPlants; TraesCAD_scaffold_011049_01G000200.1; TraesCAD_scaffold_011049_01G000200.1; TraesCAD_scaffold_011049_01G000200.
DR EnsemblPlants; TraesCLE_scaffold_048613_01G000200.1; TraesCLE_scaffold_048613_01G000200.1; TraesCLE_scaffold_048613_01G000200.
DR EnsemblPlants; TraesCS4B02G059100.1; TraesCS4B02G059100.1; TraesCS4B02G059100.
DR EnsemblPlants; TraesPAR_scaffold_001184_01G000400.1; TraesPAR_scaffold_001184_01G000400.1; TraesPAR_scaffold_001184_01G000400.
DR EnsemblPlants; TraesROB_scaffold_036282_01G000200.1; TraesROB_scaffold_036282_01G000200.1; TraesROB_scaffold_036282_01G000200.
DR EnsemblPlants; TraesWEE_scaffold_065188_01G000200.1; TraesWEE_scaffold_065188_01G000200.1; TraesWEE_scaffold_065188_01G000200.
DR Gramene; TraesCAD_scaffold_011049_01G000200.1; TraesCAD_scaffold_011049_01G000200.1; TraesCAD_scaffold_011049_01G000200.
DR Gramene; TraesCLE_scaffold_048613_01G000200.1; TraesCLE_scaffold_048613_01G000200.1; TraesCLE_scaffold_048613_01G000200.
DR Gramene; TraesCS4B02G059100.1; TraesCS4B02G059100.1; TraesCS4B02G059100.
DR Gramene; TraesPAR_scaffold_001184_01G000400.1; TraesPAR_scaffold_001184_01G000400.1; TraesPAR_scaffold_001184_01G000400.
DR Gramene; TraesROB_scaffold_036282_01G000200.1; TraesROB_scaffold_036282_01G000200.1; TraesROB_scaffold_036282_01G000200.
DR Gramene; TraesWEE_scaffold_065188_01G000200.1; TraesWEE_scaffold_065188_01G000200.1; TraesWEE_scaffold_065188_01G000200.
DR BRENDA; 2.5.1.18; 6500.
DR Proteomes; UP000019116; Unplaced.
DR ExpressionAtlas; P30111; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043295; F:glutathione binding; IBA:GO_Central.
DR GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR CDD; cd03187; GST_C_Phi; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR034347; GST_Phi_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF02798; GST_N; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SUPFAM; SSF47616; SSF47616; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 3: Inferred from homology;
KW Reference proteome; Transferase.
FT CHAIN 1..291
FT /note="Glutathione S-transferase 2"
FT /id="PRO_0000185859"
FT DOMAIN 2..83
FT /note="GST N-terminal"
FT DOMAIN 93..223
FT /note="GST C-terminal"
FT BINDING 41..42
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
FT BINDING 54..55
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
FT BINDING 67..68
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
SQ SEQUENCE 291 AA; 32580 MW; D0EB6F13D8F85909 CRC64;
MSPVKVFGHP MLTNVARVLL FLEEVGAEYE LVPVDFVAGE HKRPQHVQLN PFAKMPGFQD
GESLHIKSRA IAKYILRKYG GTAGLDLLGE NSGIEELAMV DVWTEVEAQQ YYPAISPVVF
ECIIIPFIIP GGGAAPNQTV VDESLERLRG VLGIYEARLE KSRYLAGDSI SFADLNHIPF
TFYFMTTPYA KVFDEYPKVK AWWEMLMARP AVQRVCKHMP TEFKLRARTR CLCTPRGCVP
CRAGDDPTQE KRPPSRGWVI ICPSTSSIPF QFQQHEESAC ASARASPDSL L
