GSTF5_ARATH
ID GSTF5_ARATH Reviewed; 256 AA.
AC Q9SRY6; F4HZ88;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Glutathione S-transferase F5;
DE Short=AtGSTF5;
DE EC=2.5.1.18;
DE AltName: Full=GST class-phi member 5;
GN Name=GSTF5; OrderedLocusNames=At1g02940; ORFNames=F22D16.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12090627; DOI=10.1023/a:1015557300450;
RA Wagner U., Edwards R., Dixon D.P., Mauch F.;
RT "Probing the diversity of the Arabidopsis glutathione S-transferase gene
RT family.";
RL Plant Mol. Biol. 49:515-532(2002).
CC -!- FUNCTION: May be involved in the conjugation of reduced glutathione to
CC a wide number of exogenous and endogenous hydrophobic electrophiles and
CC have a detoxification role against certain herbicides. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the GST superfamily. Phi family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF02872.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC009525; AAF02872.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27499.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59676.1; -; Genomic_DNA.
DR PIR; H86159; H86159.
DR RefSeq; NP_001322017.1; NM_001331367.1.
DR RefSeq; NP_001322019.1; NM_001331365.1.
DR RefSeq; NP_171793.1; NM_100175.2.
DR AlphaFoldDB; Q9SRY6; -.
DR SMR; Q9SRY6; -.
DR STRING; 3702.AT1G02940.1; -.
DR PaxDb; Q9SRY6; -.
DR PRIDE; Q9SRY6; -.
DR ProteomicsDB; 248517; -.
DR EnsemblPlants; AT1G02940.1; AT1G02940.1; AT1G02940.
DR EnsemblPlants; AT1G02940.4; AT1G02940.4; AT1G02940.
DR GeneID; 839479; -.
DR Gramene; AT1G02940.1; AT1G02940.1; AT1G02940.
DR Gramene; AT1G02940.4; AT1G02940.4; AT1G02940.
DR KEGG; ath:AT1G02940; -.
DR Araport; AT1G02940; -.
DR TAIR; locus:2024775; AT1G02940.
DR eggNOG; KOG0867; Eukaryota.
DR HOGENOM; CLU_011226_5_1_1; -.
DR InParanoid; Q9SRY6; -.
DR OrthoDB; 1231780at2759; -.
DR PRO; PR:Q9SRY6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SRY6; baseline and differential.
DR Genevisible; Q9SRY6; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0043295; F:glutathione binding; IBA:GO_Central.
DR GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR GO; GO:0009407; P:toxin catabolic process; TAS:TAIR.
DR CDD; cd03187; GST_C_Phi; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR034347; GST_Phi_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF02798; GST_N; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SUPFAM; SSF47616; SSF47616; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Detoxification; Reference proteome; Transferase.
FT CHAIN 1..256
FT /note="Glutathione S-transferase F5"
FT /id="PRO_0000413543"
FT DOMAIN 37..118
FT /note="GST N-terminal"
FT DOMAIN 126..256
FT /note="GST C-terminal"
FT BINDING 47..48
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
FT BINDING 76..77
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
FT BINDING 89..90
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
FT BINDING 102..103
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
SQ SEQUENCE 256 AA; 29849 MW; CF93E7D6D804C46F CRC64;
MGINASHVPE TCYHHCNQTF ESSRQCFKWC QELARKDEYK IYGYPYSTNT RRVLAVLHEK
GLSYDPITVN LIAGDQKKPS FLAINPFGQV PVFLDGGLKL TESRAISEYI ATVHKSRGTQ
LLNYKSYKTM GTQRMWMAIE SFEFDPLTST LTWEQSIKPM YGLKTDYKVV NETEAKLEKV
LDIYEERLKN SSFLASNSFT MADLYHLPNI QYLMDTHTKR MFVNRPSVRR WVAEITARPA
WKRACDVKAW YHKKKN
