GSTK1_CAEEL
ID GSTK1_CAEEL Reviewed; 226 AA.
AC Q09652;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Glutathione S-transferase kappa 1;
DE EC=2.5.1.18;
DE AltName: Full=GST class-kappa;
GN Name=gstk-1; ORFNames=ZK1320.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC -!- SIMILARITY: Belongs to the GST superfamily. Kappa family.
CC {ECO:0000305}.
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DR EMBL; Z46934; CAA87039.1; -; Genomic_DNA.
DR PIR; T27747; T27747.
DR RefSeq; NP_496082.1; NM_063681.1.
DR AlphaFoldDB; Q09652; -.
DR SMR; Q09652; -.
DR BioGRID; 56093; 5.
DR IntAct; Q09652; 1.
DR STRING; 6239.ZK1320.1; -.
DR EPD; Q09652; -.
DR PaxDb; Q09652; -.
DR PeptideAtlas; Q09652; -.
DR EnsemblMetazoa; ZK1320.1.1; ZK1320.1.1; WBGene00014251.
DR GeneID; 191563; -.
DR KEGG; cel:CELE_ZK1320.1; -.
DR CTD; 191563; -.
DR WormBase; ZK1320.1; CE01698; WBGene00014251; gstk-1.
DR eggNOG; ENOG502RH77; Eukaryota.
DR GeneTree; ENSGT00440000033697; -.
DR HOGENOM; CLU_069253_1_1_1; -.
DR InParanoid; Q09652; -.
DR OMA; CYLDCVS; -.
DR OrthoDB; 1320977at2759; -.
DR PhylomeDB; Q09652; -.
DR PRO; PR:Q09652; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00014251; Expressed in larva and 4 other tissues.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005777; C:peroxisome; IDA:WormBase.
DR GO; GO:0004602; F:glutathione peroxidase activity; IBA:GO_Central.
DR GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; HEP:WormBase.
DR CDD; cd03021; DsbA_GSTK; 1.
DR InterPro; IPR001853; DSBA-like_thioredoxin_dom.
DR InterPro; IPR044088; GSTK.
DR InterPro; IPR014440; HCCAis_GSTk.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF01323; DSBA; 1.
DR PIRSF; PIRSF006386; HCCAis_GSTk; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 3: Inferred from homology;
KW Reference proteome; Transferase.
FT CHAIN 1..226
FT /note="Glutathione S-transferase kappa 1"
FT /id="PRO_0000185895"
FT BINDING 15..17
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
FT BINDING 53
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
FT BINDING 199..200
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
SQ SEQUENCE 226 AA; 26482 MW; DBA39A5994300164 CRC64;
MPKLPRIDFY FDVISPYSYI AFEVFQKLET QWKGVTIRYI PFFLGAVMKE SGNRPPAMLP
ARSIMMMTDL KRTAKFWDIP LTPPPLFMEW IKKYRTTGAM KVLLVLQEQD KELMLRAARE
MWVRLWSRSE KIFEDQDFVE VLKAVGVKNP EQIVEKSKDE KYIKILMENT NKGVDLMAYG
APWINVHTED GSEHSFFGSD RFHLIADLLQ QPQPLPDRLF GQKSKL
