GSTU1_ORYSI
ID GSTU1_ORYSI Reviewed; 231 AA.
AC A2XMN2; O65032;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Probable glutathione S-transferase GSTU1;
DE EC=2.5.1.18;
GN Name=GSTU1; Synonyms=GST1; ORFNames=OsI_013325;
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Milyang 23;
RA Yun C.-H., Lee M.C., Park J.H., Eun M.Y.;
RT "Nucleotide sequence of rice glutathione S-transferase.";
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15069639; DOI=10.1007/s00438-004-1006-8;
RA Soranzo N., Sari Gorla M., Mizzi L., De Toma G., Frova C.;
RT "Organisation and structural evolution of the rice glutathione S-
RT transferase gene family.";
RL Mol. Genet. Genomics 271:511-521(2004).
CC -!- FUNCTION: Conjugation of reduced glutathione to a wide number of
CC exogenous and endogenous hydrophobic electrophiles.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC -!- SIMILARITY: Belongs to the GST superfamily. Tau family. {ECO:0000305}.
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DR EMBL; AF050102; AAC05216.1; -; mRNA.
DR EMBL; CM000128; EAY92092.1; -; Genomic_DNA.
DR PIR; T02765; T02765.
DR PDB; 1OYJ; X-ray; 1.95 A; A/B/C/D=1-231.
DR PDBsum; 1OYJ; -.
DR AlphaFoldDB; A2XMN2; -.
DR SMR; A2XMN2; -.
DR STRING; 39946.A2XMN2; -.
DR EnsemblPlants; BGIOSGA009694-TA; BGIOSGA009694-PA; BGIOSGA009694.
DR Gramene; BGIOSGA009694-TA; BGIOSGA009694-PA; BGIOSGA009694.
DR HOGENOM; CLU_011226_18_2_1; -.
DR OMA; YIEERWP; -.
DR Proteomes; UP000007015; Chromosome 3.
DR GO; GO:0004364; F:glutathione transferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR CDD; cd03185; GST_C_Tau; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR045074; GST_C_Tau.
DR InterPro; IPR045073; Omega/Tau-like.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11260; PTHR11260; 1.
DR Pfam; PF13417; GST_N_3; 1.
DR SFLD; SFLDG01152; Main.3:_Omega-_and_Tau-like; 1.
DR SUPFAM; SSF47616; SSF47616; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Transferase.
FT CHAIN 1..231
FT /note="Probable glutathione S-transferase GSTU1"
FT /id="PRO_0000295653"
FT DOMAIN 5..84
FT /note="GST N-terminal"
FT DOMAIN 97..220
FT /note="GST C-terminal"
FT BINDING 15
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
FT BINDING 42
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
FT BINDING 56
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
FT BINDING 68..69
FT /ligand="glutathione"
FT /ligand_id="ChEBI:CHEBI:57925"
FT /evidence="ECO:0000250"
FT CONFLICT 88
FT /note="S -> P (in Ref. 1; AAC05216)"
FT /evidence="ECO:0000305"
FT CONFLICT 90
FT /note="A -> G (in Ref. 1; AAC05216)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="Y -> F (in Ref. 1; AAC05216)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="Q -> H (in Ref. 1; AAC05216)"
FT /evidence="ECO:0000305"
FT CONFLICT 175..179
FT /note="WFYSY -> CSTAT (in Ref. 1; AAC05216)"
FT /evidence="ECO:0000305"
FT CONFLICT 201
FT /note="C -> R (in Ref. 1; AAC05216)"
FT /evidence="ECO:0000305"
FT CONFLICT 208
FT /note="A -> V (in Ref. 1; AAC05216)"
FT /evidence="ECO:0000305"
FT STRAND 6..11
FT /evidence="ECO:0007829|PDB:1OYJ"
FT HELIX 16..28
FT /evidence="ECO:0007829|PDB:1OYJ"
FT STRAND 33..36
FT /evidence="ECO:0007829|PDB:1OYJ"
FT HELIX 44..49
FT /evidence="ECO:0007829|PDB:1OYJ"
FT TURN 51..53
FT /evidence="ECO:0007829|PDB:1OYJ"
FT STRAND 58..61
FT /evidence="ECO:0007829|PDB:1OYJ"
FT STRAND 64..68
FT /evidence="ECO:0007829|PDB:1OYJ"
FT HELIX 69..79
FT /evidence="ECO:0007829|PDB:1OYJ"
FT HELIX 97..120
FT /evidence="ECO:0007829|PDB:1OYJ"
FT HELIX 127..148
FT /evidence="ECO:0007829|PDB:1OYJ"
FT STRAND 154..161
FT /evidence="ECO:0007829|PDB:1OYJ"
FT HELIX 164..169
FT /evidence="ECO:0007829|PDB:1OYJ"
FT HELIX 170..174
FT /evidence="ECO:0007829|PDB:1OYJ"
FT HELIX 176..183
FT /evidence="ECO:0007829|PDB:1OYJ"
FT HELIX 187..190
FT /evidence="ECO:0007829|PDB:1OYJ"
FT HELIX 192..201
FT /evidence="ECO:0007829|PDB:1OYJ"
FT HELIX 205..210
FT /evidence="ECO:0007829|PDB:1OYJ"
FT HELIX 214..223
FT /evidence="ECO:0007829|PDB:1OYJ"
FT TURN 224..226
FT /evidence="ECO:0007829|PDB:1OYJ"
SQ SEQUENCE 231 AA; 25832 MW; 42C953E8F540DAB0 CRC64;
MAEEKELVLL DFWVSPFGQR CRIAMAEKGL EFEYREEDLG NKSDLLLRSN PVHRKIPVLL
HAGRPVSESL VILQYLDDAF PGTPHLLSPA NSGDADAAYA RATARFWADY VDRKLYDCGS
RLWRLKGEPQ AAAGREMAEI LRTLEAELGD REFFGGGGGG RLGFVDVALV PFTAWFYSYE
RCGGFSVEEV APRLAAWARR CGRIDSVAKH LPSPEKVYDF VGVLKKKYGV E
