ID   GST_ALTAL               Reviewed;         231 AA.
AC   Q6R4B4;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Glutathione-S-transferase;
DE            EC=2.5.1.18;
DE   AltName: Allergen=Alt a 13;
OS   Alternaria alternata (Alternaria rot fungus) (Torula alternata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Alternaria;
OC   Alternaria sect. Alternaria; Alternaria alternata complex.
OX   NCBI_TaxID=5599;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND ALLERGEN.
RC   STRAIN=ITCC 4789;
RX   PubMed=16430961; DOI=10.1016/j.molimm.2005.12.006;
RA   Shankar J., Singh B.P., Gaur S.N., Arora N.;
RT   "Recombinant glutathione-S-transferase a major allergen from Alternaria
RT   alternata for clinical use in allergy patients.";
RL   Mol. Immunol. 43:1927-1932(2006).
CC   -!- FUNCTION: Conjugation of reduced glutathione to a wide number of
CC       exogenous and endogenous hydrophobic electrophiles.
CC       {ECO:0000269|PubMed:16430961}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glutathione + RX = a halide anion + an S-substituted
CC         glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC         ChEBI:CHEBI:90779; EC=2.5.1.18;
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC       {ECO:0000269|PubMed:16430961}.
CC   -!- SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}.
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DR   EMBL; AY514673; AAR98813.1; -; mRNA.
DR   AlphaFoldDB; Q6R4B4; -.
DR   SMR; Q6R4B4; -.
DR   Allergome; 2542; Alt a 13.
DR   Allergome; 3060; Alt a 13.0101.
DR   PRIDE; Q6R4B4; -.
DR   GO; GO:0004364; F:glutathione transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF13409; GST_N_2; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   1: Evidence at protein level;
KW   Allergen; Transferase.
FT   CHAIN           1..231
FT                   /note="Glutathione-S-transferase"
FT                   /id="PRO_0000345088"
FT   DOMAIN          15..98
FT                   /note="GST N-terminal"
SQ   SEQUENCE   231 AA;  26562 MW;  4320AFD16D5D5699 CRC64;
     MSDKPSELAV QKLVLFAVKG TATSTHNTVR PLILLDELGV PHEIYVVDRV SAPWFTEINP
     HRMVPVILEK SPDGRDTLRA WESTSTLMYI ADAYDKDGTF GGRNVQESSD INNWLTLHTA
     ALGPTAKYWL YFYKLHPEKL PKTIEKLRSN ITVQYDILER RLNEPGQQYL AWLNEKFKRS
     SYNRRHCYAS LCYEKYRRVV RAGVKVAQTA RVVCPYGGDT RRGVWPARKS T