GSX1_MOUSE
ID GSX1_MOUSE Reviewed; 261 AA.
AC P31315;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=GS homeobox 1;
DE AltName: Full=Homeobox protein GSH-1;
GN Name=Gsx1; Synonyms=Gsh-1, Gsh1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=NIH Swiss;
RX PubMed=8589431; DOI=10.1002/aja.1002030306;
RA Valerius M.T., Li H., Stock J.L., Weinstein M., Kaur S., Singh G.,
RA Potter S.S.;
RT "Gsh-1: a novel murine homeobox gene expressed in the central nervous
RT system.";
RL Dev. Dyn. 203:337-351(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=8631293; DOI=10.1002/j.1460-2075.1996.tb00407.x;
RA Li H., Zeitler P.S., Valerius M.T., Small K., Potter S.S.;
RT "Gsh-1, an orphan Hox gene, is required for normal pituitary development.";
RL EMBO J. 15:714-724(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 146-205.
RX PubMed=1683707; DOI=10.1073/pnas.88.23.10706;
RA Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA Potter S.S.;
RT "Identification of 10 murine homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991).
CC -!- FUNCTION: Probable transcription factor that binds to the DNA sequence
CC 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene.
CC Plays an important role in pituitary development.
CC {ECO:0000269|PubMed:8631293}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U21224; AAA96814.1; -; mRNA.
DR CCDS; CCDS19877.1; -.
DR PIR; S63604; S63604.
DR RefSeq; NP_032204.1; NM_008178.2.
DR AlphaFoldDB; P31315; -.
DR SMR; P31315; -.
DR BioGRID; 200085; 1.
DR IntAct; P31315; 1.
DR STRING; 10090.ENSMUSP00000069728; -.
DR iPTMnet; P31315; -.
DR PhosphoSitePlus; P31315; -.
DR PaxDb; P31315; -.
DR PRIDE; P31315; -.
DR Antibodypedia; 22686; 75 antibodies from 17 providers.
DR DNASU; 14842; -.
DR Ensembl; ENSMUST00000065382; ENSMUSP00000069728; ENSMUSG00000053129.
DR GeneID; 14842; -.
DR KEGG; mmu:14842; -.
DR UCSC; uc009anw.1; mouse.
DR CTD; 219409; -.
DR MGI; MGI:95842; Gsx1.
DR VEuPathDB; HostDB:ENSMUSG00000053129; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000154361; -.
DR HOGENOM; CLU_077153_0_0_1; -.
DR InParanoid; P31315; -.
DR OMA; GACHSRK; -.
DR OrthoDB; 1341872at2759; -.
DR PhylomeDB; P31315; -.
DR TreeFam; TF315938; -.
DR BioGRID-ORCS; 14842; 3 hits in 72 CRISPR screens.
DR PRO; PR:P31315; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P31315; protein.
DR Bgee; ENSMUSG00000053129; Expressed in renal glomerulus and 67 other tissues.
DR ExpressionAtlas; P31315; baseline and differential.
DR Genevisible; P31315; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0021984; P:adenohypophysis development; IMP:MGI.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0021854; P:hypothalamus development; IMP:MGI.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0048663; P:neuron fate commitment; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; IGI:MGI.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..261
FT /note="GS homeobox 1"
FT /id="PRO_0000048895"
FT DNA_BIND 146..205
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..20
FT /note="SNAG domain"
FT /evidence="ECO:0000250"
FT REGION 201..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 261 AA; 27728 MW; BA9D6B94359E4FF3 CRC64;
MPRSFLVDSL VLREASDKKA PEGSPPPLFP YAVPPPHALH GLSPGACHAR KAGLLCVCPL
CVTASQLHGP PGPPALPLLK ASFPPFGSQY CHAPLGRQHS VSPGVAHGPA AAAAAAALYQ
TSYPLPDPRQ FHCISVDSSS NQLPSSKRMR TAFTSTQLLE LEREFASNMY LSRLRRIEIA
TYLNLSEKQV KIWFQNRRVK HKKEGKGSNH RGGAGAGAGG GAPQGCKCSS LSSAKCSEDD
DELPMSPSSS GKDDRDLTVT P
