GSXL1_ARATH
ID GSXL1_ARATH Reviewed; 468 AA.
AC Q9FWW6;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Flavin-containing monooxygenase FMO GS-OX-like 1;
DE EC=1.8.-.-;
DE AltName: Full=Flavin-monooxygenase glucosinolate S-oxygenase-like 1;
GN OrderedLocusNames=At1g12160; ORFNames=T28K15.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Bautista V.R., Chen H., De Los Reyes C., Wu S.Y., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=17461789; DOI=10.1111/j.1365-313x.2007.03101.x;
RA Hansen B.G., Kliebenstein D.J., Halkier B.A.;
RT "Identification of a flavin-monooxygenase as the S-oxygenating enzyme in
RT aliphatic glucosinolate biosynthesis in Arabidopsis.";
RL Plant J. 50:902-910(2007).
CC -!- FUNCTION: Catalyzes the conversion of methylthioalkyl glucosinolates of
CC any chain length into methylsulfinylalkyl glucosinolates.
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the FMO family. {ECO:0000305}.
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DR EMBL; AC022522; AAG12577.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28844.1; -; Genomic_DNA.
DR EMBL; BT030389; ABO45692.1; -; mRNA.
DR PIR; F86256; F86256.
DR RefSeq; NP_172680.1; NM_101088.4.
DR AlphaFoldDB; Q9FWW6; -.
DR SMR; Q9FWW6; -.
DR BioGRID; 23008; 2.
DR IntAct; Q9FWW6; 1.
DR STRING; 3702.AT1G12160.1; -.
DR PaxDb; Q9FWW6; -.
DR PRIDE; Q9FWW6; -.
DR ProteomicsDB; 247193; -.
DR EnsemblPlants; AT1G12160.1; AT1G12160.1; AT1G12160.
DR GeneID; 837768; -.
DR Gramene; AT1G12160.1; AT1G12160.1; AT1G12160.
DR KEGG; ath:AT1G12160; -.
DR Araport; AT1G12160; -.
DR TAIR; locus:2202038; AT1G12160.
DR eggNOG; KOG1399; Eukaryota.
DR HOGENOM; CLU_006909_3_0_1; -.
DR InParanoid; Q9FWW6; -.
DR OMA; GCWVSRD; -.
DR OrthoDB; 405736at2759; -.
DR PhylomeDB; Q9FWW6; -.
DR BioCyc; ARA:AT1G12160-MON; -.
DR PRO; PR:Q9FWW6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FWW6; baseline and differential.
DR Genevisible; Q9FWW6; AT.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0019761; P:glucosinolate biosynthetic process; IMP:TAIR.
DR GO; GO:0009753; P:response to jasmonic acid; IEP:TAIR.
DR GO; GO:0009751; P:response to salicylic acid; IEP:TAIR.
DR Gene3D; 3.50.50.60; -; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000960; Flavin_mOase.
DR InterPro; IPR020946; Flavin_mOase-like.
DR Pfam; PF00743; FMO-like; 2.
DR PRINTS; PR00370; FMOXYGENASE.
DR SUPFAM; SSF51905; SSF51905; 2.
PE 2: Evidence at transcript level;
KW FAD; Flavoprotein; Monooxygenase; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..468
FT /note="Flavin-containing monooxygenase FMO GS-OX-like 1"
FT /id="PRO_0000401956"
FT BINDING 16..21
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT BINDING 211..216
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000255"
SQ SEQUENCE 468 AA; 53271 MW; 5D1FA79463CD4F20 CRC64;
MTSVITSRAR HVAVIGLGAA GLVAVRELRR EGHTVIGFER EKHVGGLWVY TDRVDSDSVS
VDPDRTIVHS SIYQSLRTNL PRECMGYSDF PFVTRSSDGD PRRYPDHREV LMYLQDFAKE
FKIEDMIRFE TEVLCVEPSP ENNRKWRVQF KSSNGVSGEE IFDAVVVCNG HFTEPRLAHI
PGIESWPGKQ IHSHNYRIPD PFKDEVVIVI GSQASGNDIS TDIATIAKEV HISSKMVASD
SYGCYDNLRI HPTIYRARED GSVVFRNGKV VFADAIVHCT GYKYHFPFLK TSGYVTVEDN
RVGPLYKHVF PPALAPGISF IGLPFMGLQF FMFEIQSKWV ASVLSGRVKL PAEDKMMEEA
VAFYSKLEDL GIPKRYTHFL TDPRGNPMLG TFKPEDAVVI SQSDYFNWIA KQCGCTSIER
WRERLYNVAI KKVFFGGDSY RDRWDDDQLI EEVYREFAKL KPNQDCSS
