GSXL3_ARATH
ID GSXL3_ARATH Reviewed; 450 AA.
AC Q9SXD5;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Flavin-containing monooxygenase FMO GS-OX-like 3;
DE EC=1.8.-.-;
DE AltName: Full=Flavin-monooxygenase glucosinolate S-oxygenase-like 3;
GN OrderedLocusNames=At1g62620; ORFNames=T3P18.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=17461789; DOI=10.1111/j.1365-313x.2007.03101.x;
RA Hansen B.G., Kliebenstein D.J., Halkier B.A.;
RT "Identification of a flavin-monooxygenase as the S-oxygenating enzyme in
RT aliphatic glucosinolate biosynthesis in Arabidopsis.";
RL Plant J. 50:902-910(2007).
CC -!- FUNCTION: Catalyzes the conversion of methylthioalkyl glucosinolates of
CC any chain length into methylsulfinylalkyl glucosinolates.
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the FMO family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD43619.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BX815465; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR EMBL; AC005698; AAD43619.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33987.1; -; Genomic_DNA.
DR EMBL; BX815465; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_176450.2; NM_104940.4.
DR AlphaFoldDB; Q9SXD5; -.
DR SMR; Q9SXD5; -.
DR STRING; 3702.AT1G62620.1; -.
DR PaxDb; Q9SXD5; -.
DR PRIDE; Q9SXD5; -.
DR ProteomicsDB; 247226; -.
DR EnsemblPlants; AT1G62620.1; AT1G62620.1; AT1G62620.
DR GeneID; 842559; -.
DR Gramene; AT1G62620.1; AT1G62620.1; AT1G62620.
DR KEGG; ath:AT1G62620; -.
DR Araport; AT1G62620; -.
DR TAIR; locus:2203866; AT1G62620.
DR eggNOG; KOG1399; Eukaryota.
DR HOGENOM; CLU_006909_3_0_1; -.
DR InParanoid; Q9SXD5; -.
DR OrthoDB; 405736at2759; -.
DR PhylomeDB; Q9SXD5; -.
DR BioCyc; ARA:AT1G62620-MON; -.
DR PRO; PR:Q9SXD5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SXD5; baseline and differential.
DR Genevisible; Q9SXD5; AT.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR Gene3D; 3.50.50.60; -; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000960; Flavin_mOase.
DR InterPro; IPR020946; Flavin_mOase-like.
DR Pfam; PF00743; FMO-like; 2.
DR PIRSF; PIRSF000332; FMO; 1.
DR PRINTS; PR00370; FMOXYGENASE.
DR SUPFAM; SSF51905; SSF51905; 2.
PE 2: Evidence at transcript level;
KW FAD; Flavoprotein; Monooxygenase; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..450
FT /note="Flavin-containing monooxygenase FMO GS-OX-like 3"
FT /id="PRO_0000401958"
FT BINDING 17..22
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT BINDING 215..220
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000255"
SQ SEQUENCE 450 AA; 51256 MW; 747DAB7B07562E2F CRC64;
MAPALSPTRS HHVAVIGAGP AGLVAARELR REGHSVVVFE KQKQVGGTWI YTDEVESDPL
SVDPTRSVVH SSVYRSLRIN GTRECTGYRD FPFVVRSGVS RDPRRFPSHG EVLAYLKDFA
KEFGIEEMVR FETEVVKVSP AAEEGIGKWR IESTEKEKKV RRDEIYDAVV VCNGHYVEPR
LAQIPGISSW PGKEMHSHNY RIPEPFRDKV VVLIGNSSSA EDISRDIARV AKEVHVACRS
NPADTFIKQT GYNNLWTHSM IESVHEDGSV VYQNGKTISV DIIMHCTGYK YHFPFLDTNG
IVTVDDNRVG PLYKDVFPPA FAPWLSFIGI PWQVLPFPMF ELQSKWIAGV LSGRIPLPSK
EDMMIEIKTF YSTLEVQGIP KRYTHRMGNT QFEYYNWLAS QCGCSETEEW RKEMCLANGV
RKEAHPETYR DEWDDHHLVS EAYQDFSLYS
