GSXL5_ARATH
ID GSXL5_ARATH Reviewed; 450 AA.
AC Q9C8U0; Q9SH23;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Flavin-containing monooxygenase FMO GS-OX-like 5;
DE EC=1.8.-.-;
DE AltName: Full=Flavin-monooxygenase glucosinolate S-oxygenase-like 5;
GN OrderedLocusNames=At1g63370; ORFNames=F2K11.25, F9N12.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=17461789; DOI=10.1111/j.1365-313x.2007.03101.x;
RA Hansen B.G., Kliebenstein D.J., Halkier B.A.;
RT "Identification of a flavin-monooxygenase as the S-oxygenating enzyme in
RT aliphatic glucosinolate biosynthesis in Arabidopsis.";
RL Plant J. 50:902-910(2007).
CC -!- FUNCTION: Catalyzes the conversion of methylthioalkyl glucosinolates of
CC any chain length into methylsulfinylalkyl glucosinolates.
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the FMO family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF19700.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG52151.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC008047; AAF19700.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC022355; AAG52151.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34091.1; -; Genomic_DNA.
DR RefSeq; NP_176526.1; NM_105016.2.
DR AlphaFoldDB; Q9C8U0; -.
DR SMR; Q9C8U0; -.
DR STRING; 3702.AT1G63370.1; -.
DR PaxDb; Q9C8U0; -.
DR PRIDE; Q9C8U0; -.
DR DNASU; 842643; -.
DR EnsemblPlants; AT1G63370.1; AT1G63370.1; AT1G63370.
DR GeneID; 842643; -.
DR Gramene; AT1G63370.1; AT1G63370.1; AT1G63370.
DR KEGG; ath:AT1G63370; -.
DR Araport; AT1G63370; -.
DR TAIR; locus:2031336; AT1G63370.
DR eggNOG; KOG1399; Eukaryota.
DR HOGENOM; CLU_006909_3_0_1; -.
DR InParanoid; Q9C8U0; -.
DR OMA; VMMADII; -.
DR OrthoDB; 405736at2759; -.
DR PhylomeDB; Q9C8U0; -.
DR BioCyc; ARA:AT1G63370-MON; -.
DR PRO; PR:Q9C8U0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C8U0; baseline and differential.
DR Genevisible; Q9C8U0; AT.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR Gene3D; 3.50.50.60; -; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000960; Flavin_mOase.
DR InterPro; IPR020946; Flavin_mOase-like.
DR Pfam; PF00743; FMO-like; 2.
DR PIRSF; PIRSF000332; FMO; 1.
DR PRINTS; PR00370; FMOXYGENASE.
DR SUPFAM; SSF51905; SSF51905; 2.
PE 2: Evidence at transcript level;
KW FAD; Flavoprotein; Monooxygenase; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..450
FT /note="Flavin-containing monooxygenase FMO GS-OX-like 5"
FT /id="PRO_0000401960"
FT BINDING 17..22
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT BINDING 215..220
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000255"
SQ SEQUENCE 450 AA; 51239 MW; 809F531378528B20 CRC64;
MAPALSPTRS HHVAVIGAGP AGLVAARELR REGHSVVVFE KQKQVGGTWI YTDEVESDPL
SVDPTRSVVH SSVYRSLRIN GTRECTGYRD FPFVVRSGVS RDRRRFPSHG EVLAYLKDFA
KEFGIEEMVR FETEVVKVSP AAEEGIGKWR IESTEKEKKV RRDEIYDAVV VCNGHYVEPR
LAQIPGISSW PGKEMHSHNY RIPEPFRDKV AVLIGNSSSA EDISRDIARV AKEVHVACRS
NPADTFIKQT GYNNLWTHSM IESVHEDGSV VYQNGKTISV DIIMHCTGYK YHFPFLDTNG
IVTVDDNRVG PLYKDVFPPA FAPWLSFIGI PWQVLPFPMF ELQSKWIAGV LSGRIPLPSK
EDMMIEIKTF YSTLEVQGIP KRYTHRMGNT QFEYDNWLAS QCGCSETEEW RKEMCLANGV
RKEAHPETYR DEWDDHHLVS EAYQDFSLYS
