GSXL6_ARATH
ID GSXL6_ARATH Reviewed; 470 AA.
AC Q9FWW3;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Flavin-containing monooxygenase FMO GS-OX-like 6;
DE EC=1.8.-.-;
DE AltName: Full=Flavin-monooxygenase glucosinolate S-oxygenase-like 6;
GN OrderedLocusNames=At1g12130; ORFNames=T28K15.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF Clones.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=17461789; DOI=10.1111/j.1365-313x.2007.03101.x;
RA Hansen B.G., Kliebenstein D.J., Halkier B.A.;
RT "Identification of a flavin-monooxygenase as the S-oxygenating enzyme in
RT aliphatic glucosinolate biosynthesis in Arabidopsis.";
RL Plant J. 50:902-910(2007).
CC -!- FUNCTION: Catalyzes the conversion of methylthioalkyl glucosinolates of
CC any chain length into methylsulfinylalkyl glucosinolates.
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the FMO family. {ECO:0000305}.
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DR EMBL; AC022522; AAG12580.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28840.1; -; Genomic_DNA.
DR EMBL; DQ056453; AAY78610.1; -; mRNA.
DR EMBL; BT026366; ABH04473.1; -; mRNA.
DR PIR; C86256; C86256.
DR RefSeq; NP_172677.1; NM_101085.2.
DR AlphaFoldDB; Q9FWW3; -.
DR SMR; Q9FWW3; -.
DR STRING; 3702.AT1G12130.1; -.
DR PaxDb; Q9FWW3; -.
DR PRIDE; Q9FWW3; -.
DR ProteomicsDB; 247139; -.
DR EnsemblPlants; AT1G12130.1; AT1G12130.1; AT1G12130.
DR GeneID; 837765; -.
DR Gramene; AT1G12130.1; AT1G12130.1; AT1G12130.
DR KEGG; ath:AT1G12130; -.
DR Araport; AT1G12130; -.
DR TAIR; locus:2201981; AT1G12130.
DR eggNOG; KOG1399; Eukaryota.
DR HOGENOM; CLU_006909_3_0_1; -.
DR InParanoid; Q9FWW3; -.
DR OMA; LYQHVVW; -.
DR OrthoDB; 405736at2759; -.
DR PhylomeDB; Q9FWW3; -.
DR BioCyc; ARA:AT1G12130-MON; -.
DR PRO; PR:Q9FWW3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FWW3; baseline and differential.
DR Genevisible; Q9FWW3; AT.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0019761; P:glucosinolate biosynthetic process; IMP:TAIR.
DR GO; GO:0009737; P:response to abscisic acid; IEP:TAIR.
DR GO; GO:0009753; P:response to jasmonic acid; IEP:TAIR.
DR GO; GO:0009751; P:response to salicylic acid; IEP:TAIR.
DR Gene3D; 3.50.50.60; -; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000960; Flavin_mOase.
DR InterPro; IPR020946; Flavin_mOase-like.
DR Pfam; PF00743; FMO-like; 2.
DR PRINTS; PR00370; FMOXYGENASE.
DR SUPFAM; SSF51905; SSF51905; 2.
PE 2: Evidence at transcript level;
KW FAD; Flavoprotein; Monooxygenase; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..470
FT /note="Flavin-containing monooxygenase FMO GS-OX-like 6"
FT /id="PRO_0000401961"
FT BINDING 17..22
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT BINDING 214..219
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000255"
SQ SEQUENCE 470 AA; 53837 MW; 6345C99AE5110919 CRC64;
MTPPPNSISS RNVAVIGAGA AGLVAARELR REGHTVTIFE RQKQVGGLWV CTPNVEPDLL
SIDPDRTVVH SSVYQSLRTN LPRECMGYSD FPFVTRPDDE SRDPRRYPDH REVMRYLQDF
AKEFKIEEMI RFETEVFRVE PTAENSCKWR VQFRSSSGVS GEDIFDAVVI CNGHFTEPRL
AHIPGIESWP GKQIHSHNYR VSDPFKGQVV IVIGYQSSGS DISRDIAILA KEVHIAAKSD
AYAKESSIYS NLHFHPTIDR VYEDGSVVFQ DGKLIFADAI VHCTGYKYCF PFLETKGYVN
VEDNRVGPLY KHVFPPALAP GLSFIGLPSM ALQFFMFEIQ SRWVASVLSG RVKLPSEEQM
MEDVIAFYAK LKSLGIPKRF THFLTDPQWT PMFEKLKPHE AVLISQSEYF NWIAEQCGCS
SIERWREEQY NIAIKKDDDN FRDEWDDDDQ IIQEAYRDFA KFKPSKVWST
