GSXL7_ARATH
ID GSXL7_ARATH Reviewed; 464 AA.
AC Q9SXD9; F4HYU0;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Flavin-containing monooxygenase FMO GS-OX-like 7;
DE EC=1.8.-.-;
DE AltName: Full=Flavin-monooxygenase glucosinolate S-oxygenase-like 7;
GN OrderedLocusNames=At1g62580; ORFNames=T3P18.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=17461789; DOI=10.1111/j.1365-313x.2007.03101.x;
RA Hansen B.G., Kliebenstein D.J., Halkier B.A.;
RT "Identification of a flavin-monooxygenase as the S-oxygenating enzyme in
RT aliphatic glucosinolate biosynthesis in Arabidopsis.";
RL Plant J. 50:902-910(2007).
CC -!- FUNCTION: Catalyzes the conversion of methylthioalkyl glucosinolates of
CC any chain length into methylsulfinylalkyl glucosinolates.
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the FMO family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD43615.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEE33980.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005698; AAD43615.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33980.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; ANM58707.1; -; Genomic_DNA.
DR RefSeq; NP_001321123.1; NM_001334039.1.
DR RefSeq; NP_176446.1; NM_104936.2.
DR AlphaFoldDB; Q9SXD9; -.
DR SMR; Q9SXD9; -.
DR STRING; 3702.AT1G62580.1; -.
DR PRIDE; Q9SXD9; -.
DR ProteomicsDB; 248521; -.
DR EnsemblPlants; AT1G62580.2; AT1G62580.2; AT1G62580.
DR GeneID; 842555; -.
DR Gramene; AT1G62580.2; AT1G62580.2; AT1G62580.
DR KEGG; ath:AT1G62580; -.
DR Araport; AT1G62580; -.
DR TAIR; locus:2203911; AT1G62580.
DR eggNOG; KOG1399; Eukaryota.
DR HOGENOM; CLU_006909_3_0_1; -.
DR InParanoid; Q9SXD9; -.
DR OMA; MAWINDG; -.
DR OrthoDB; 405736at2759; -.
DR PhylomeDB; Q9SXD9; -.
DR BioCyc; ARA:AT1G62580-MON; -.
DR PRO; PR:Q9SXD9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SXD9; baseline and differential.
DR Genevisible; Q9SXD9; AT.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IDA:TAIR.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0070026; F:nitric oxide binding; IDA:TAIR.
DR GO; GO:0019825; F:oxygen binding; IDA:TAIR.
DR GO; GO:0090332; P:stomatal closure; IMP:TAIR.
DR Gene3D; 3.50.50.60; -; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000960; Flavin_mOase.
DR InterPro; IPR020946; Flavin_mOase-like.
DR Pfam; PF00743; FMO-like; 2.
DR PRINTS; PR00370; FMOXYGENASE.
DR SUPFAM; SSF51905; SSF51905; 2.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Monooxygenase; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..464
FT /note="Flavin-containing monooxygenase FMO GS-OX-like 7"
FT /id="PRO_0000401962"
FT BINDING 18..23
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT BINDING 214..219
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000255"
SQ SEQUENCE 464 AA; 53076 MW; BC2FA21F89856822 CRC64;
MVPAVNPPTT SNHVAVIGAG AAGLVAAREL RREGHSVVVF ERGNHIGGVW AYTPNVEPDP
LSIDPTRPVI HSSLYSSLRT IIPQECMGFT DFPFSTRLEN GSRDPRRHPG HSEVLAYLRD
FVREFKIEEM IRFETEVVRV EQAGENPKKW RVKSRNFGDI SDEIYDAVVV CNGHYTEPRH
ALIPGIDTWP GKQIHSHNYR VPEQVKDQVV VVIGSSVSGV DISRDIANVT KEVHISSRST
KPETYEKLPG YDNLWLHSNI ETVREDGSVV FKNGKTVYAD TIMHCTGYKY YFPFLDTKGE
VTVEDNRVGP LYKHVFPPAL SPGLSFIGLP WQVIPFPMFE LQSKWVAAVL AGRVSLPSQE
EMEDTKMFYL KLEASCIPKR YTHLMAELDS QFVYNNWLAD QCDYPRIEKW REQMFYKVFK
RIQSQASTYK DDWDDDHLIA EAYEDFVKFP SNYPSSLIER EYTS
