GSXLX_ARATH
ID GSXLX_ARATH Reviewed; 448 AA.
AC Q9C8T8; F4I223;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 3.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Putative flavin-containing monooxygenase FMO GS-OX-like 10;
DE EC=1.8.-.-;
DE AltName: Full=Putative flavin-monooxygenase glucosinolate S-oxygenase-like 10;
GN OrderedLocusNames=At1g63340; ORFNames=F9N12.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=17461789; DOI=10.1111/j.1365-313x.2007.03101.x;
RA Hansen B.G., Kliebenstein D.J., Halkier B.A.;
RT "Identification of a flavin-monooxygenase as the S-oxygenating enzyme in
RT aliphatic glucosinolate biosynthesis in Arabidopsis.";
RL Plant J. 50:902-910(2007).
CC -!- FUNCTION: Catalyzes the conversion of methylthioalkyl glucosinolates of
CC any chain length into methylsulfinylalkyl glucosinolates.
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the FMO family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG52152.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG52152.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AEE34088.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC022355; AAG52152.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34088.1; ALT_SEQ; Genomic_DNA.
DR PIR; D96659; D96659.
DR RefSeq; NP_176523.4; NM_105013.4.
DR AlphaFoldDB; Q9C8T8; -.
DR SMR; Q9C8T8; -.
DR STRING; 3702.AT1G63340.1; -.
DR PRIDE; Q9C8T8; -.
DR GeneID; 842640; -.
DR KEGG; ath:AT1G63340; -.
DR Araport; AT1G63340; -.
DR eggNOG; KOG1399; Eukaryota.
DR HOGENOM; CLU_006909_3_0_1; -.
DR InParanoid; Q9C8T8; -.
DR OrthoDB; 405736at2759; -.
DR BioCyc; ARA:AT1G63340-MON; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C8T8; baseline and differential.
DR Genevisible; Q9C8T8; AT.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR Gene3D; 3.50.50.60; -; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000960; Flavin_mOase.
DR InterPro; IPR020946; Flavin_mOase-like.
DR Pfam; PF00743; FMO-like; 2.
DR PRINTS; PR00370; FMOXYGENASE.
DR SUPFAM; SSF51905; SSF51905; 2.
PE 5: Uncertain;
KW FAD; Flavoprotein; Monooxygenase; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..448
FT /note="Putative flavin-containing monooxygenase FMO GS-OX-
FT like 10"
FT /id="PRO_0000401965"
FT BINDING 18..23
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT BINDING 212..217
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000255"
SQ SEQUENCE 448 AA; 51118 MW; 73ED1563FDB8B253 CRC64;
MVPAVNPPTT SHHVAVIGAG AAGLVAAREL RREGHSVVVF ERGNQIGGVW AYTPNVEPDP
LSIDPTRPVI HSSLYSSLRT IIPRECMGFT DFPFSTGPEN KSRDPRRHPG HIEVLAYLKD
FARKFKMDEM IRFETEVVRA EPAAENPKKW RVESRNSGDI SDEIYDAVVV CNGHYTEPRH
ALIPGIDSCP GKQIHSHNYR IPDQFKDQLN SGSSVSGVDI SRDIVNVTKE VHISSRSTKP
ETYEKLSGYD NLWLHSNIET VREDGSVVFK NGKTVYADTI MHCTGYKYYF PFLDTKGEVT
VEDNRVGPLY KHVFPPALSP GLSFIGLPWQ VILFPMFELQ SKWVAAVLAG RFYSKLEASC
IPKRYTHLMA ELDSQFVYDN WLADQCDYPR IEKWREQMFY KVFKRIQSQS STYKDDWDDD
HLIAEAYEDF VKFPSNYPSS LIEREYTS