ID   GT253_RAT               Reviewed;         572 AA.
AC   Q5U309;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Probable inactive glycosyltransferase 25 family member 3;
DE   AltName: Full=Cerebral endothelial cell adhesion molecule;
GN   Name=Cercam; Synonyms=Ceecam1, Glt25d3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable cell adhesion protein involved in leukocyte
CC       transmigration across the blood-brain barrier. Does not express any
CC       beta-galactosyltransferase activity in vitro.
CC       {ECO:0000250|UniProtKB:Q5T4B2}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-
CC       ProRule:PRU10138}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 25 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH85782.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC085782; AAH85782.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001011962.1; NM_001011962.1.
DR   RefSeq; XP_006233831.1; XM_006233769.3.
DR   RefSeq; XP_017447134.1; XM_017591645.1.
DR   RefSeq; XP_017447135.1; XM_017591646.1.
DR   RefSeq; XP_017447136.1; XM_017591647.1.
DR   RefSeq; XP_017447137.1; XM_017591648.1.
DR   AlphaFoldDB; Q5U309; -.
DR   SMR; Q5U309; -.
DR   STRING; 10116.ENSRNOP00000057689; -.
DR   CAZy; GT25; Glycosyltransferase Family 25.
DR   GlyGen; Q5U309; 4 sites.
DR   PaxDb; Q5U309; -.
DR   GeneID; 296616; -.
DR   KEGG; rno:296616; -.
DR   UCSC; RGD:1304778; rat.
DR   CTD; 51148; -.
DR   RGD; 1304778; Cercam.
DR   VEuPathDB; HostDB:ENSRNOG00000026604; -.
DR   eggNOG; KOG4179; Eukaryota.
DR   HOGENOM; CLU_024037_2_0_1; -.
DR   InParanoid; Q5U309; -.
DR   OMA; NRQRQGC; -.
DR   OrthoDB; 931915at2759; -.
DR   PRO; PR:Q5U309; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000026604; Expressed in esophagus and 19 other tissues.
DR   ExpressionAtlas; Q5U309; baseline and differential.
DR   Genevisible; Q5U309; RN.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0007155; P:cell adhesion; ISO:RGD.
DR   CDD; cd06532; Glyco_transf_25; 1.
DR   InterPro; IPR002654; Glyco_trans_25.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF01755; Glyco_transf_25; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00014; ER_TARGET; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Endoplasmic reticulum; Glycoprotein; Reference proteome.
FT   CHAIN           1..572
FT                   /note="Probable inactive glycosyltransferase 25 family
FT                   member 3"
FT                   /id="PRO_0000309546"
FT   MOTIF           569..572
FT                   /note="Prevents secretion from ER"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10138"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        130
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        214
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        337
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   572 AA;  65223 MW;  ACBF436060A5D1E8 CRC64;
     MLFIIRARAC GGDARSWKQP DQLHPILFTN LRLPLQLIAS SAGGATDHNV DNTTGMLQEW
     LAAVGRDYAT VVWKSEDEAR SYPDEQGPKH WTRERHQFLM ELKQEALAFA RDWGADYILF
     ADTDNILTNN QTLRLLIDRQ LPVVAPMLDS QTYYSNFWCG ITPQGYYRRT AEYFPTKNRQ
     RQGCFRVPMV HSTFLVSLQT EETARLAFYP PHPNYTWPFD DIIVFAYACQ AAGVSVHVCN
     DHRYGYMNVG VKPHQGLEEE KTNFIHLILE ALVDGPPMMA SAHVSRPPKK PSKMGFDEVF
     VISLARRPQR RARMLSSLWE MEISARVVDA VDGRTLNSSI LKHLGVDLLP GYQDPYSGRT
     LTKGEVGCFL SHYSIWEEVV AKGLARVVVF EDDVRFEDNF RKRLERLMED VLTQKLSWDL
     IYLGRKQVNP EEEVAVEGLP GLVVAGYSYW TLAYTLSLAG ARKLLASQPL HRMLPVDEFL
     PVMFDRHPND QYKAHFWPRD LQAFSARPLL ASPTHYAGDT EWLSDTETSS PWDDDSGRLI
     SWTGSQKTLR GPYLHLAGSS GHSLHPHPRD EL