ID   GT2D2_BOVIN             Reviewed;         950 AA.
AC   A4IFA3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=General transcription factor II-I repeat domain-containing protein 2;
DE            Short=GTF2I repeat domain-containing protein 2;
DE   AltName: Full=Transcription factor GTF2IRD2;
GN   Name=GTF2IRD2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the TFII-I family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00484}.
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DR   EMBL; BC134477; AAI34478.1; -; mRNA.
DR   RefSeq; NP_001077214.1; NM_001083745.1.
DR   AlphaFoldDB; A4IFA3; -.
DR   SMR; A4IFA3; -.
DR   STRING; 9913.ENSBTAP00000012908; -.
DR   PaxDb; A4IFA3; -.
DR   PRIDE; A4IFA3; -.
DR   Ensembl; ENSBTAT00000012908; ENSBTAP00000012908; ENSBTAG00000026286.
DR   GeneID; 539745; -.
DR   KEGG; bta:539745; -.
DR   CTD; 84163; -.
DR   VEuPathDB; HostDB:ENSBTAG00000026286; -.
DR   eggNOG; ENOG502QS6T; Eukaryota.
DR   GeneTree; ENSGT00940000162266; -.
DR   InParanoid; A4IFA3; -.
DR   OMA; HHCAKVL; -.
DR   OrthoDB; 788135at2759; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000026286; Expressed in thyroid gland and 105 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0014883; P:transition between fast and slow fiber; IEA:Ensembl.
DR   Gene3D; 3.90.1460.10; -; 2.
DR   InterPro; IPR025398; DUF4371.
DR   InterPro; IPR004212; GTF2I.
DR   InterPro; IPR036647; GTF2I-like_rpt_sf.
DR   InterPro; IPR042224; GTF2IRD2.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR040647; SPIN-DOC_Znf-C2H2.
DR   PANTHER; PTHR47831; PTHR47831; 1.
DR   Pfam; PF14291; DUF4371; 1.
DR   Pfam; PF02946; GTF2I; 2.
DR   Pfam; PF18658; zf-C2H2_12; 1.
DR   SUPFAM; SSF117773; SSF117773; 2.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS51139; GTF2I; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..950
FT                   /note="General transcription factor II-I repeat domain-
FT                   containing protein 2"
FT                   /id="PRO_0000320119"
FT   REPEAT          100..194
FT                   /note="GTF2I-like 1"
FT   REPEAT          324..418
FT                   /note="GTF2I-like 2"
SQ   SEQUENCE   950 AA;  107016 MW;  62409644CAF02CBD CRC64;
     MAQVAVSTPP IAHEESSESR MVVTFLVSAL ESMCKELAKS KAEVACIAMY EADVFVIGTE
     KGRAFVNART DLQKDFAKYC VAEGLQEVKP PGPANASRMQ VDSGETEILR KAVEDYFCFC
     YGKALGTAAM VPVPYEKMLT DQEAIVVQGL PEGVPFQHPE NYDLATLKWI LENKAGISFL
     INRPFPGPAN QPGGPGVVTD TDKSVTSPSE SCTPIRVKTE PMEDSGISLK AEVVSVKKES
     EDPNYYEYSM QESRHSSAGT EVIETELPME DSIQLVPSET SEDPEAEVKI EGNTSSPNIT
     NSAAGVEDLN IVQVTVPDNE KERLSSLEKI KQLREQVNDL FSRKFGEAIG VDFPVKVPYR
     KITFNPGCVV IDGMPPGVVF KAPGYLEISS MRRILDAADL IKFTVIRPLP GLELSNVGKR
     KIDQEGRVFQ EKWERAYFFV EVQNIPTCLI CKQSMSVSKE YNLRRHYQTN HSKHYDQYTE
     KMRDEKLQEL KEGLRKYLLG SSDTVCPEQK QVFAKVNPRE NAAVQPVEDV AGNLWEKLRE
     KIRSFVAYSI AIDEITDINN TTQLAIFIRG VDENFDVSEE LLDTVPMTGT KSGNEIFLRV
     EKSLKKFNID WSKLVSVAST GTPAMVDAND GLVTKLKSKV AMVCKGSDLK SVCCIIHPES
     LCAQKLKMDH IMSVVVNAVN WICSRGLNHS EFTTLLYELD CQYGSLLYYT EIKWLSRGLV
     LKRFFESLEE IDSFMSSRGK PLPQLSSQDW IKDLAFLVDM TMHLNTLNIS LQGHSQIVTQ
     MYDLIRAFLA KLCLWETHLA RNNLAHFPTL KSVSRNESDG LNYIPKIVEL KTEFQKRLSD
     FKLYESELTL FSSPFSMKIE SVQEALQMEV IDLQCNTVLK TKYDKVGIPE FYKHLWGSYP
     KYKIHCAKIL SMFGSTYICE QLFSIMKLSK TEYCSQLKDS QWDSVLHIST