GTAA_DICDI
ID GTAA_DICDI Reviewed; 872 AA.
AC Q550D5; P90523; Q86AP1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Transcription factor stalky;
DE AltName: Full=GATA zinc finger domain-containing protein 1;
GN Name=stkA; Synonyms=gatA; ORFNames=DDB_G0277147;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR
RP LOCATION, AND DEVELOPMENTAL STAGE.
RC STRAIN=NC-4;
RX PubMed=8898200; DOI=10.1016/s0092-8674(00)81367-7;
RA Chang W.-T., Newell P.C., Gross J.D.;
RT "Identification of the cell fate gene stalky in Dictyostelium.";
RL Cell 87:471-481(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [4]
RP FUNCTION IN EXPRESSION OF CULC; CULD; RNPA AND SIGB.
RX PubMed=11100898; DOI=10.1046/j.1432-0436.2000.660202.x;
RA Loughran G., Pinter K., Newell P.C., Gross J.D.;
RT "Identification of STKA-dependent genes in Dictyostelium discoideum.";
RL Differentiation 66:71-80(2000).
CC -!- FUNCTION: Probable transcription factor. Seems to act on the expression
CC of the genes culC, culD, rnpA and sigB. {ECO:0000269|PubMed:11100898,
CC ECO:0000269|PubMed:8898200}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8898200}.
CC -!- DEVELOPMENTAL STAGE: Strongly expressed in the prespore region of
CC aggregates but not in the anterior prestalk zone.
CC {ECO:0000269|PubMed:8898200}.
CC -!- DISRUPTION PHENOTYPE: Cells destined to become spores end up as stalk
CC cells. {ECO:0000269|PubMed:8898200}.
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DR EMBL; U68754; AAB36702.1; -; mRNA.
DR EMBL; AAFI02000019; EAL68759.1; -; Genomic_DNA.
DR RefSeq; XP_642681.1; XM_637589.1.
DR AlphaFoldDB; Q550D5; -.
DR SMR; Q550D5; -.
DR STRING; 44689.DDB0185187; -.
DR PaxDb; Q550D5; -.
DR EnsemblProtists; EAL68759; EAL68759; DDB_G0277147.
DR GeneID; 8620870; -.
DR KEGG; ddi:DDB_G0277147; -.
DR dictyBase; DDB_G0277147; stkA.
DR eggNOG; ENOG502RSU0; Eukaryota.
DR HOGENOM; CLU_329411_0_0_1; -.
DR InParanoid; Q550D5; -.
DR OMA; INQHLQM; -.
DR PRO; PR:Q550D5; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:dictyBase.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045595; P:regulation of cell differentiation; IMP:dictyBase.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:dictyBase.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00320; GATA; 1.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..872
FT /note="Transcription factor stalky"
FT /id="PRO_0000330434"
FT ZN_FING 294..319
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 15..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 161
FT /note="S -> L (in Ref. 1; AAB36702)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="P -> T (in Ref. 1; AAB36702)"
FT /evidence="ECO:0000305"
FT CONFLICT 546
FT /note="P -> H (in Ref. 1; AAB36702)"
FT /evidence="ECO:0000305"
FT CONFLICT 758
FT /note="S -> T (in Ref. 1; AAB36702)"
FT /evidence="ECO:0000305"
FT CONFLICT 764
FT /note="D -> E (in Ref. 1; AAB36702)"
FT /evidence="ECO:0000305"
FT CONFLICT 773
FT /note="L -> I (in Ref. 1; AAB36702)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 872 AA; 99004 MW; 91418D5A53585747 CRC64;
MMGEFHTQFQ QIKQNNINNN NNNNNNNSNN NNNFDPITSL TNNNNNKIIS PLNSNRQQPN
SNTNNNSNNK NNNKSNLLDI ILDNNNLENN IDNNNNNNNN NNNNNNNNNN NNSKSIINLI
DNNNNNNKNN NNNNNNNNIL KIPIDYTPVD KNTESIFKGF SPFSFKQQQP IDTSDQQQKE
TKKLQLNINS NNKNNNNIIN NSNNNNNINN IESNNNNLNS ASTSPIPTPT SLTAVSVPSS
SPLPSPTSPN TILQSPTTTT TTTTTTSNSS VSPQPTQINK TDKYLLPMSA PRSCEFCGSS
QTPTWRRGPS GKGSLCNACG IKWRLKGKDG IFKPSQKQQN RQKPIMSAQK QPKQQQNQPQ
QQQPQQPQQP QQPQQQNQQQ NQQQSIQSQP QQRQNNHLIL NQQTINQHLQ MLSKQHQQQA
SQSMFQQQQL HNNQHSNDSN YNSYNNNNNN NNNNYSQHEQ LPPISSYNSM NNNNNSNNSN
NNNNNNNYSQ IPQYGSDDNV SVPNQSPDSY KPSKKRKPEF IHTDTSGNPI EFEKGYYCKY
CKKTWPQSSF RNSQQFGAHC SNCSRKPKGE LEELISIKKK LSKKKSKEGN YYQEEDGAVP
YWDMNRYNNN NNNNNGINNN NNNNNNNNNN NSNNNGSYNN NNSNNNNNNN RIEPIVNNNI
NNFNSINNNN SNNNNNNNST SQNAPLLQRL IHVVENQLLE PNELSSIRED IDIMKNDLIL
RKKKRIAQLN DLKQKANNDV QILKANIEKG SNQRSNESKS FITDLKQEID KRLNQYTHIY
IPPDHHLVPS STNYLSIDSL QNSSSSNNYG TIHNSNNNNN NNNNNNKRSL VNLSPELIHS
PLKKPMVGGY RDEQGMKHFS IDGDNLSLPS IS
