GTAB2_STAS1
ID GTAB2_STAS1 Reviewed; 289 AA.
AC Q49VP4;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase 2;
DE EC=2.7.7.9;
DE AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase 2;
DE AltName: Full=UDP-glucose pyrophosphorylase 2;
DE Short=UDPGP 2;
DE AltName: Full=Uridine diphosphoglucose pyrophosphorylase 2;
GN Name=gtaB2; OrderedLocusNames=SSP2021;
OS Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS 20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=342451;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT pathogenesis of uncomplicated urinary tract infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC -!- FUNCTION: Catalyzes the formation of UDP-glucose from glucose-1-
CC phosphate and UTP. This is an intermediate step in the biosynthesis of
CC diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the
CC membrane, which is also used as a membrane anchor for lipoteichoic acid
CC (LTA) (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9;
CC -!- PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
CC -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR EMBL; AP008934; BAE19166.1; -; Genomic_DNA.
DR RefSeq; WP_011303674.1; NZ_CP035294.1.
DR AlphaFoldDB; Q49VP4; -.
DR SMR; Q49VP4; -.
DR STRING; 342451.SSP2021; -.
DR EnsemblBacteria; BAE19166; BAE19166; SSP2021.
DR GeneID; 66868180; -.
DR KEGG; ssp:SSP2021; -.
DR eggNOG; COG1210; Bacteria.
DR HOGENOM; CLU_029499_1_2_9; -.
DR OMA; MKYITSV; -.
DR OrthoDB; 1402673at2; -.
DR UniPathway; UPA00894; -.
DR Proteomes; UP000006371; Chromosome.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR CDD; cd02541; UGPase_prokaryotic; 1.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43197; PTHR43197; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
DR TIGRFAMs; TIGR01099; galU; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Nucleotidyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..289
FT /note="UTP--glucose-1-phosphate uridylyltransferase 2"
FT /id="PRO_0000308314"
SQ SEQUENCE 289 AA; 32658 MW; D8140ABBCCAEB036 CRC64;
MRKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEAARAGI EDIIIVTGKH
KRAIEDHFDN QKELEMILQE KGKTDLLEKV KYSTELANIF YVRQKEQKGL GHAIYSARQF
IGDEPFAVLL GDDIVESDNP AIKQLIEAYE ETGKSVIGVQ EVDEAQTHRY GIIDPLQKFG
RKYEVNEFVE KPKQGTAPSN LAIMGRYVLT PDIFDYLATQ GEGAGGEIQL TDAIERLNRA
DQVYAYDFEG DRYDVGEKLG FVKTTIEYAL KDESMHDELV EFIKKLKLN
