ID   GTAB_STAA8              Reviewed;         288 AA.
AC   Q2G1T6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE            EC=2.7.7.9;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE   AltName: Full=UDP-glucose pyrophosphorylase;
DE            Short=UDPGP;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN   Name=gtaB; OrderedLocusNames=SAOUHSC_02801;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   FUNCTION IN GLYCOLIPID AND LTA BIOSYNTHESIS, AND PATHWAY.
RX   PubMed=17209021; DOI=10.1128/jb.01683-06;
RA   Gruendling A., Schneewind O.;
RT   "Genes required for glycolipid synthesis and lipoteichoic acid anchoring in
RT   Staphylococcus aureus.";
RL   J. Bacteriol. 189:2521-2530(2007).
CC   -!- FUNCTION: Catalyzes the formation of UDP-glucose from glucose-1-
CC       phosphate and UTP (Probable). This is an intermediate step in the
CC       biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the
CC       predominant glycolipid found in the S.aureus membrane, which is also
CC       used as a membrane anchor for lipoteichoic acid (LTA).
CC       {ECO:0000269|PubMed:17209021, ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC         alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885; EC=2.7.7.9;
CC   -!- PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
CC       {ECO:0000269|PubMed:17209021}.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABD31804.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000253; ABD31804.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000721336.1; NZ_LS483365.1.
DR   RefSeq; YP_501260.1; NC_007795.1.
DR   AlphaFoldDB; Q2G1T6; -.
DR   SMR; Q2G1T6; -.
DR   STRING; 1280.SAXN108_2747; -.
DR   EnsemblBacteria; ABD31804; ABD31804; SAOUHSC_02801.
DR   GeneID; 3921455; -.
DR   KEGG; sao:SAOUHSC_02801; -.
DR   PATRIC; fig|93061.5.peg.2533; -.
DR   eggNOG; COG1210; Bacteria.
DR   HOGENOM; CLU_029499_1_3_9; -.
DR   BioCyc; MetaCyc:MON-20001; -.
DR   UniPathway; UPA00894; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   CDD; cd02541; UGPase_prokaryotic; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43197; PTHR43197; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..288
FT                   /note="UTP--glucose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000308301"
SQ   SEQUENCE   288 AA;  32451 MW;  126BF005599D4418 CRC64;
     MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEAARAGI EDIIIVTGRH
     KRAIEDHFDS QKELEMVLKE KGKSELLEKV QYSTELANIF YVRQKEQKGL GHAISSARQF
     IGNEPFAVLL GDDIVESEVP AVKQLIDVYE ETGHSVIGVQ EVPEADTHRY GIIDPLTKNG
     RQYEVKKFVE KPAQGTAPSN LAIMGRYVLT PEIFDYLKTQ KEGAGNEIQL TDAIERMNND
     NQVYAYDFEG ERYDVGEKLG FVKTTIEYAL KDDSMREELT RFIKALGL