GTAB_STAES
ID GTAB_STAES Reviewed; 288 AA.
AC Q8CR67;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE EC=2.7.7.9;
DE AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE AltName: Full=UDP-glucose pyrophosphorylase;
DE Short=UDPGP;
DE AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN Name=gtaB; OrderedLocusNames=SE_2043;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- FUNCTION: Catalyzes the formation of UDP-glucose from glucose-1-
CC phosphate and UTP. This is an intermediate step in the biosynthesis of
CC diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the
CC membrane, which is also used as a membrane anchor for lipoteichoic acid
CC (LTA) (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9;
CC -!- PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
CC -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO05684.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE015929; AAO05684.1; ALT_FRAME; Genomic_DNA.
DR RefSeq; NP_765598.1; NC_004461.1.
DR RefSeq; WP_001831553.1; NZ_WBME01000003.1.
DR AlphaFoldDB; Q8CR67; -.
DR SMR; Q8CR67; -.
DR STRING; 176280.SE_2043; -.
DR EnsemblBacteria; AAO05684; AAO05684; SE_2043.
DR KEGG; sep:SE_2043; -.
DR PATRIC; fig|176280.10.peg.1996; -.
DR eggNOG; COG1210; Bacteria.
DR HOGENOM; CLU_029499_1_3_9; -.
DR UniPathway; UPA00894; -.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR CDD; cd02541; UGPase_prokaryotic; 1.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43197; PTHR43197; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
DR TIGRFAMs; TIGR01099; galU; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Nucleotidyltransferase; Transferase.
FT CHAIN 1..288
FT /note="UTP--glucose-1-phosphate uridylyltransferase"
FT /id="PRO_0000308311"
SQ SEQUENCE 288 AA; 32424 MW; ED5422E73E60672F CRC64;
MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEASKAGI EDIIIVTGKH
KRAIEDHFDN QKELEMVLEN KGKADLLEKV QYSTDLANIF YVRQKEQKGL GHAIHTAKQF
IGNEPFAVLL GDDIVESDTP AIKQLMDVYE ETGHSVIGVQ EVPESDTHRY GVIDPSAKEG
SRYEVRQFVE KPKQGTAPSN LAIMGRYVLT PEIFDYLETQ QEGAGNEIQL TDAIERMNSK
QQVYAYDFEG NRYDVGEKLG FVKTTIEYAL KDPEMSQDLK AFIKQLDI
