ID   GTCR_ANEMI              Reviewed;         242 AA.
AC   Q44929;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Response regulator GtcR;
GN   Name=gtcR;
OS   Aneurinibacillus migulanus (Bacillus migulanus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae;
OC   Aneurinibacillus group; Aneurinibacillus.
OX   NCBI_TaxID=47500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 9999 / DSM 2895 / JCM 8504 / NBRC 15520 / NCIMB 7096 / NCTC
RC   7096;
RX   PubMed=7579582; DOI=10.3109/10425179509030982;
RA   Turgay K., Marahiel M.A.;
RT   "The gtcRS operon coding for two-component system regulatory proteins is
RT   located adjacent to the grs operon of Bacillus brevis.";
RL   DNA Seq. 5:283-290(1995).
CC   -!- FUNCTION: Member of the two-component regulatory system GtcS/GtcR which
CC       may act in the control of the transcription of the grs operon which
CC       encodes the multienzymes involved in the biosynthesis of the peptide
CC       antibiotic gramicidin S.
CC   -!- PTM: Phosphorylated by GtcS. {ECO:0000305}.
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DR   EMBL; X78502; CAA55264.1; -; Genomic_DNA.
DR   PIR; I40084; I40084.
DR   AlphaFoldDB; Q44929; -.
DR   SMR; Q44929; -.
DR   STRING; 47500.AF333_17635; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..242
FT                   /note="Response regulator GtcR"
FT                   /id="PRO_0000081291"
FT   DOMAIN          4..117
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        133..233
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         53
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   242 AA;  28115 MW;  C5F66E988AB1D770 CRC64;
     MSKTILIADD EPEIIELLKL FLERESYRII EAYDGEQAWN YIRQHPVDLA IIDIMMPALD
     GFQLIKRLTN EYKLPVIILS AKNRDSDKIL GLGLGADDFI SKPFNPLEAV ARIQAQLRRA
     FEFNEPEEKA ISTQSTTVGR LTLLHTACVV YRGDETYSVT PLEYRLLNTF MQCSRTSIFT
     KQQLFEQAWS ETYWEDDNTI MVQISRLRDK IEDQPRQPVY IKTVRGLGYK FASKDDFDEE
     KT