ID   GTDC1_DANRE             Reviewed;         433 AA.
AC   Q568B7; B0S8J7;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Glycosyltransferase-like domain-containing protein 1;
GN   Name=gtdc1; ORFNames=si:dkey-52o2.3, zgc:110568;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
CC       Glycosyltransferase 4 subfamily. {ECO:0000305}.
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DR   EMBL; BX936460; CAQ15307.1; -; Genomic_DNA.
DR   EMBL; CR925716; CAQ15307.1; JOINED; Genomic_DNA.
DR   EMBL; CR925716; CAQ14815.1; -; Genomic_DNA.
DR   EMBL; BX936460; CAQ14815.1; JOINED; Genomic_DNA.
DR   EMBL; BC092932; AAH92932.1; -; mRNA.
DR   RefSeq; NP_001017560.1; NM_001017560.1.
DR   AlphaFoldDB; Q568B7; -.
DR   STRING; 7955.ENSDARP00000016818; -.
DR   CAZy; GT4; Glycosyltransferase Family 4.
DR   PaxDb; Q568B7; -.
DR   Ensembl; ENSDART00000024572; ENSDARP00000016818; ENSDARG00000020642.
DR   Ensembl; ENSDART00000127135; ENSDARP00000109130; ENSDARG00000020642.
DR   GeneID; 550132; -.
DR   KEGG; dre:550132; -.
DR   CTD; 79712; -.
DR   ZFIN; ZDB-GENE-050417-8; gtdc1.
DR   eggNOG; ENOG502QQJ3; Eukaryota.
DR   GeneTree; ENSGT00390000006631; -.
DR   HOGENOM; CLU_033439_1_0_1; -.
DR   InParanoid; Q568B7; -.
DR   OMA; HRWEYDK; -.
DR   OrthoDB; 583461at2759; -.
DR   PhylomeDB; Q568B7; -.
DR   TreeFam; TF324818; -.
DR   PRO; PR:Q568B7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000020642; Expressed in blastula and 24 other tissues.
DR   ExpressionAtlas; Q568B7; baseline.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0007417; P:central nervous system development; IMP:ZFIN.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR022701; GlycosylTrfase_1_N.
DR   Pfam; PF12038; DUF3524; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..433
FT                   /note="Glycosyltransferase-like domain-containing protein
FT                   1"
FT                   /id="PRO_0000311092"
FT   REGION          194..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        54
FT                   /note="P -> L (in Ref. 2; AAH92932)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        432
FT                   /note="M -> L (in Ref. 2; AAH92932)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   433 AA;  49737 MW;  237CE823458A5849 CRC64;
     MSVLLLEAFY GGSHKQLLDL LKESVEDCVS FTLPAKKWHW RARTSALYFM QAVPANSSYR
     VLFTSSVLNL AELVALRPDL GHLKKVLYFH ENQLVYPVRK SQERDFQYGY NQILSCLVAD
     VVVFNSSFNM ESFLSSISTF MKTMPDHRPK DLERLIRPKC HVLHFPIRFP DVTRFLPAHK
     RLRHPVRCDD IHAPAAKSHI QTSSPSSYPD VEPPEKMLNV AGTNQSHEPT SVTPHQETAS
     PLCGHEGEKL RPLHIVWPHR WEHDKDPQLF FQTLLKLKDR QLSFEVSVLG ETFTDVPDIF
     SEAKEQLVDH IQHWGFMPSK EDYLKVLCQA DVVVSTAKHE FFGVAMLEAV HCGCYPLCPK
     ALVYPEIFPA TYLYSTPEQL CKRLQEFCKR PQLARQHVVQ VSLSSFSWDS LGDNFRSLLK
     ADSGRMFTDK HMA