GTDC1_MOUSE
ID GTDC1_MOUSE Reviewed; 445 AA.
AC Q8BW56; A2AQR9; A2AQS2; A2AVU2; Q3TQ41; Q80US3; Q8C1B8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Glycosyltransferase-like domain-containing protein 1;
GN Name=Gtdc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Ovary, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 84-445.
RC STRAIN=C57BL/6J;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BW56-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BW56-2; Sequence=VSP_029380;
CC Name=3;
CC IsoId=Q8BW56-3; Sequence=VSP_029381, VSP_029382;
CC -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
CC Glycosyltransferase 4 subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH52069.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC35713.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK028468; BAC25967.1; -; mRNA.
DR EMBL; AK054272; BAC35713.1; ALT_INIT; mRNA.
DR EMBL; AK163943; BAE37544.1; -; mRNA.
DR EMBL; AL844891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL935057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX293544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC052069; AAH52069.1; ALT_INIT; mRNA.
DR CCDS; CCDS71050.1; -. [Q8BW56-1]
DR RefSeq; NP_766250.2; NM_172662.3. [Q8BW56-1]
DR RefSeq; XP_011237391.1; XM_011239089.2.
DR RefSeq; XP_011237392.1; XM_011239090.2.
DR RefSeq; XP_011237393.1; XM_011239091.2. [Q8BW56-1]
DR AlphaFoldDB; Q8BW56; -.
DR STRING; 10090.ENSMUSP00000108429; -.
DR CAZy; GT4; Glycosyltransferase Family 4.
DR iPTMnet; Q8BW56; -.
DR PhosphoSitePlus; Q8BW56; -.
DR MaxQB; Q8BW56; -.
DR PaxDb; Q8BW56; -.
DR PRIDE; Q8BW56; -.
DR ProteomicsDB; 270900; -. [Q8BW56-1]
DR ProteomicsDB; 270901; -. [Q8BW56-2]
DR ProteomicsDB; 270902; -. [Q8BW56-3]
DR Antibodypedia; 33618; 164 antibodies from 24 providers.
DR DNASU; 227835; -.
DR Ensembl; ENSMUST00000100127; ENSMUSP00000097703; ENSMUSG00000036890. [Q8BW56-3]
DR Ensembl; ENSMUST00000112810; ENSMUSP00000108429; ENSMUSG00000036890. [Q8BW56-1]
DR GeneID; 227835; -.
DR KEGG; mmu:227835; -.
DR UCSC; uc008jpa.2; mouse. [Q8BW56-1]
DR CTD; 79712; -.
DR MGI; MGI:2444269; Gtdc1.
DR VEuPathDB; HostDB:ENSMUSG00000036890; -.
DR eggNOG; ENOG502QQJ3; Eukaryota.
DR GeneTree; ENSGT00390000006631; -.
DR HOGENOM; CLU_033439_1_0_1; -.
DR InParanoid; Q8BW56; -.
DR OMA; HRWEYDK; -.
DR OrthoDB; 583461at2759; -.
DR PhylomeDB; Q8BW56; -.
DR TreeFam; TF324818; -.
DR BioGRID-ORCS; 227835; 1 hit in 68 CRISPR screens.
DR ChiTaRS; Gtdc1; mouse.
DR PRO; PR:Q8BW56; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BW56; protein.
DR Bgee; ENSMUSG00000036890; Expressed in animal zygote and 226 other tissues.
DR ExpressionAtlas; Q8BW56; baseline and differential.
DR Genevisible; Q8BW56; MM.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR022701; GlycosylTrfase_1_N.
DR Pfam; PF12038; DUF3524; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..445
FT /note="Glycosyltransferase-like domain-containing protein
FT 1"
FT /id="PRO_0000311089"
FT REGION 199..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 61..106
FT /note="TLFASSVLNLTELAALRPDLGKLKKILYFHENQLVYPVKKYQERDF -> RR
FT RSWNCCCVPDHRTGFTFCLTVSKNNTEKFFLARDWTSELRSSLF (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029381"
FT VAR_SEQ 107..445
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029382"
FT VAR_SEQ 280..445
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029380"
SQ SEQUENCE 445 AA; 51017 MW; 66ED0D66008FE809 CRC64;
MSIVIIEAFY GGSHRQLVEL LREELDDCVL YTLPAKKWHW RARTAALYFS QNIPSSEHYR
TLFASSVLNL TELAALRPDL GKLKKILYFH ENQLVYPVKK YQERDFQYGY NQILSCLVAD
VVVFNSSFNM ESFLTSIGKF LKLIPDHRPK DLESIIRPKC QVIYFPIRFP DVSRFMPKHK
IAHLRRMLSL IGDAAASQSV APCPQPGQRV SEKSPENCES KSDEHPDLDA EQEALDNPSV
HKSGSLPVSK ENLPLDPSTL LCGAEDPQRP LHITWPHRWE HDKDPETFLK ILMSLKQLNL
NFHVSVLGET FTDTPDIFSE AKKALGSSVL HWGYLPRKED YFRVLCMADV VISTAKHEFF
GVAMLEAVYC GCYPLCPKAL VYPEIFPAEY LYSTPEQLSK RLKSFCKRPD IIRKHLYKGE
VAPFSWAALH GKFRSLLTTE PREDL
