GTE4_ARATH
ID GTE4_ARATH Reviewed; 766 AA.
AC Q9LNC4;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Transcription factor GTE4;
DE AltName: Full=Bromodomain-containing protein GTE4;
DE AltName: Full=Protein GLOBAL TRANSCRIPTION FACTOR GROUP E4;
GN Name=GTE4; OrderedLocusNames=At1g06230; ORFNames=F9P14.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12466527; DOI=10.1093/nar/gkf660;
RA Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S.,
RA Richards E.J., Bender J., Mount D.W., Jorgensen R.A.;
RT "Analysis of histone acetyltransferase and histone deacetylase families of
RT Arabidopsis thaliana suggests functional diversification of chromatin
RT modification among multicellular eukaryotes.";
RL Nucleic Acids Res. 30:5036-5055(2002).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX PubMed=20032077; DOI=10.1104/pp.109.150631;
RA Airoldi C.A., Rovere F.D., Falasca G., Marino G., Kooiker M.,
RA Altamura M.M., Citterio S., Kater M.M.;
RT "The Arabidopsis BET bromodomain factor GTE4 is involved in maintenance of
RT the mitotic cell cycle during plant development.";
RL Plant Physiol. 152:1320-1334(2010).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20495359; DOI=10.4161/psb.5.6.11571;
RA Della Rovere F., Airoldi C.A., Falasca G., Ghiani A., Fattorini L.,
RA Citterio S., Kater M., Altamura M.M.;
RT "The Arabidopsis BET bromodomain factor GTE4 regulates the mitotic cell
RT cycle.";
RL Plant Signal. Behav. 5:677-680(2010).
CC -!- FUNCTION: Involved in the activation and maintenance of cell division
CC in the meristems and by this controls cell numbers in differentiated
CC organs. Its action in cell cycle regulation may be directed through the
CC RB-E2F pathway. {ECO:0000269|PubMed:20032077,
CC ECO:0000269|PubMed:20495359}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:20032077}.
CC -!- DOMAIN: The NET domain could serve as an interface to localize
CC different proteins or complexes to chromatin.
CC -!- DISRUPTION PHENOTYPE: Cell numbers are significantly reduced in most of
CC the organs. Cell cycle reactivation is delayed in germinating seeds,
CC and a premature switch from mitosis to endoreduplication occurs.
CC Furthermore, a partial loss of root quiescent center (QC) identity is
CC observed. {ECO:0000269|PubMed:20032077, ECO:0000269|PubMed:20495359}.
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DR EMBL; AC025290; AAF80220.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27964.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27965.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27966.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60626.1; -; Genomic_DNA.
DR PIR; A86198; A86198.
DR RefSeq; NP_001184922.1; NM_001197993.2.
DR RefSeq; NP_001318932.1; NM_001331622.1.
DR RefSeq; NP_172113.1; NM_100505.3.
DR RefSeq; NP_849601.1; NM_179270.2.
DR AlphaFoldDB; Q9LNC4; -.
DR SMR; Q9LNC4; -.
DR STRING; 3702.AT1G06230.1; -.
DR iPTMnet; Q9LNC4; -.
DR PaxDb; Q9LNC4; -.
DR PRIDE; Q9LNC4; -.
DR ProteomicsDB; 247341; -.
DR EnsemblPlants; AT1G06230.1; AT1G06230.1; AT1G06230.
DR EnsemblPlants; AT1G06230.2; AT1G06230.2; AT1G06230.
DR EnsemblPlants; AT1G06230.3; AT1G06230.3; AT1G06230.
DR EnsemblPlants; AT1G06230.4; AT1G06230.4; AT1G06230.
DR GeneID; 837133; -.
DR Gramene; AT1G06230.1; AT1G06230.1; AT1G06230.
DR Gramene; AT1G06230.2; AT1G06230.2; AT1G06230.
DR Gramene; AT1G06230.3; AT1G06230.3; AT1G06230.
DR Gramene; AT1G06230.4; AT1G06230.4; AT1G06230.
DR KEGG; ath:AT1G06230; -.
DR Araport; AT1G06230; -.
DR TAIR; locus:2038565; AT1G06230.
DR eggNOG; KOG1474; Eukaryota.
DR HOGENOM; CLU_009580_2_0_1; -.
DR InParanoid; Q9LNC4; -.
DR OMA; NREMRFV; -.
DR OrthoDB; 529089at2759; -.
DR PhylomeDB; Q9LNC4; -.
DR PRO; PR:Q9LNC4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LNC4; baseline and differential.
DR Genevisible; Q9LNC4; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0009294; P:DNA-mediated transformation; IMP:TAIR.
DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; IMP:TAIR.
DR GO; GO:0048364; P:root development; IMP:TAIR.
DR CDD; cd05506; Bromo_plant1; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; -; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR037377; GTE_bromo.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; SSF47370; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51525; NET; 1.
PE 2: Evidence at transcript level;
KW Bromodomain; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..766
FT /note="Transcription factor GTE4"
FT /id="PRO_0000406336"
FT DOMAIN 433..505
FT /note="Bromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT DOMAIN 597..678
FT /note="NET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00857"
FT REGION 87..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..766
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 84095 MW; 344C05545FC6A104 CRC64;
MASEPVNGGE GIDGAREKQI IKVYKRKGKG QRKQSSFFAL EAAIEKPEGL LENENDNNDV
SPAETLAPEF EDPIVVVKNS IEEAALGTNS HGDKNLTEAP SENLPGDDSD KVIDKPLVEA
FSQAQPQDDA SLAAMDKSEE VPSQIPKAQD DVNTVVVDEN SIKEPPKSLA QEDVTTVIVD
KNPIEAPSQT LSLEDGDTLV VDKNPIEVSS EEDVHVIDAD NLIKEAHPEN FVERDTTDAQ
QPAGLTSDSA HATAAGSMPM EEDADGRIRI HVASTTKQQK EEIRKKLEDQ LNVVRGMVKK
IEDKEGEIGA YNDSRVLINT GINNGGGRIL SGFASAGLPR EVIRAPRPVN QLSISVLENT
QGVNEHVEKE KRTPKANQFY RNSEFLLGDK LPPAESNKKS KSSSKKQGGD VGHGFGAGTK
VFKNCSALLE RLMKHKHGWV FNAPVDVKGL GLLDYYTIIE HPMDLGTIKS ALMKNLYKSP
REFAEDVRLT FHNAMTYNPE GQDVHLMAVT LLQIFEERWA VIEADYNREM RFVTGYEMNL
PTPTMRSRLG PTMPPPPINV RNTIDRADWS NRQPTTTPGR TPTSATPSGR TPALKKPKAN
EPNKRDMTYE EKQKLSGHLQ NLPPDKLDAI VQIVNKRNTA VKLRDEEIEV DIDSVDPETL
WELDRFVTNY KKGLSKKKRK AELAIQARAE AERNSQQQMA PAPAAHEFSR EGGNTAKKTL
PTPLPSQVEK QNNETSRSSS SSSSSSSSSS SDSDSDSSSS SGSDQT
