GTE6_ARATH
ID GTE6_ARATH Reviewed; 369 AA.
AC Q9FT54;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transcription factor GTE6;
DE AltName: Full=Bromodomain-containing protein GTE6;
DE AltName: Full=Protein GENERAL TRANSCRIPTION FACTOR GROUP E6;
DE AltName: Full=Protein GLOBAL TRANSCRIPTION FACTOR GROUP E6;
GN Name=GTE6; OrderedLocusNames=At3g52280; ORFNames=T25B15.50;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12466527; DOI=10.1093/nar/gkf660;
RA Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S.,
RA Richards E.J., Bender J., Mount D.W., Jorgensen R.A.;
RT "Analysis of histone acetyltransferase and histone deacetylase families of
RT Arabidopsis thaliana suggests functional diversification of chromatin
RT modification among multicellular eukaryotes.";
RL Nucleic Acids Res. 30:5036-5055(2002).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=16166385; DOI=10.1101/gad.352005;
RA Chua Y.L., Channeliere S., Mott E., Gray J.C.;
RT "The bromodomain protein GTE6 controls leaf development in Arabidopsis by
RT histone acetylation at ASYMMETRIC LEAVES1.";
RL Genes Dev. 19:2245-2254(2005).
CC -!- FUNCTION: Regulates differences in leaf patterning between juvenile and
CC mature leaves by controlling differences in the development of
CC primordia produced during juvenile and mature phases. Acts by
CC activating transcription of the myb-domain protein AS1, a gene involved
CC in leaf-axis specification. Associates with the promoter and the start
CC of the transcribed region of AS1 and up-regulates expression of AS1
CC through acetylation of histones H3 and H4.
CC {ECO:0000269|PubMed:16166385}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16166385}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9FT54-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Abundantly expressed in flowers. Weakly expressed
CC in roots, leaves and siliques; and undetectable in 5-day-old seedlings.
CC In the basal rosette leaves of 21-day-old plants, it is more abundant
CC in leaves 6 and 7, which possess narrow elliptical laminae, than in
CC leaves 1-4, which have round laminae, suggesting a possible correlation
CC between its expression and the formation of elliptical leaf laminae in
CC mature leaves. {ECO:0000269|PubMed:16166385}.
CC -!- DOMAIN: The NET domain could serve as an interface to localize
CC different proteins or complexes to chromatin.
CC -!- DISRUPTION PHENOTYPE: Disrupted formation of elliptical leaf laminae in
CC mature leaves. {ECO:0000269|PubMed:16166385}.
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DR EMBL; AL132972; CAC07919.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78925.1; -; Genomic_DNA.
DR PIR; T46098; T46098.
DR RefSeq; NP_190796.1; NM_115088.2. [Q9FT54-1]
DR AlphaFoldDB; Q9FT54; -.
DR SMR; Q9FT54; -.
DR STRING; 3702.AT3G52280.2; -.
DR PRIDE; Q9FT54; -.
DR ProteomicsDB; 247231; -. [Q9FT54-1]
DR EnsemblPlants; AT3G52280.1; AT3G52280.1; AT3G52280. [Q9FT54-1]
DR GeneID; 824393; -.
DR Gramene; AT3G52280.1; AT3G52280.1; AT3G52280. [Q9FT54-1]
DR KEGG; ath:AT3G52280; -.
DR Araport; AT3G52280; -.
DR eggNOG; KOG1474; Eukaryota.
DR HOGENOM; CLU_063149_0_0_1; -.
DR InParanoid; Q9FT54; -.
DR OMA; MEPVMAS; -.
DR PhylomeDB; Q9FT54; -.
DR PRO; PR:Q9FT54; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9FT54; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; -; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR017413; GTE1.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PIRSF; PIRSF038154; Transcription_factor_GTE6; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; SSF47370; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51525; NET; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Bromodomain; Chromatin regulator;
KW Coiled coil; Developmental protein; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..369
FT /note="Transcription factor GTE6"
FT /id="PRO_0000211204"
FT DOMAIN 106..181
FT /note="Bromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT DOMAIN 250..331
FT /note="NET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00857"
FT REGION 329..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 201..263
FT /evidence="ECO:0000255"
FT MOTIF 351..368
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 329..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 369 AA; 42393 MW; 006F48BAD3216C58 CRC64;
MADSVPGHVA GGGLQGFSVD AECIKQRVDE VLQWVDSLEH KLKEVEEFYS SIGVSNSGSI
GKDTEKGRHV VGIRKIQQEA ARREAVAAKR MQDLMRQFGT IFRQITQHKC AWPFMHPVNV
EGLGLHDYFE VIDKPMDFST IKNQMEAKDG TGYKHVMQIY ADMRLVFENA MNYNEETSDV
YSMAKKLLEK FEEKWAHFLP KVQEEEKIRE EEEKQAAKEA LLAKEASHIK TTRELGNEIC
HANDELEKLM RKVVERCRKI TIEEKRNIGL ALLKLSPDDL QKVLGIVAQA NPSFQPRAEE
VSIEMDILDE PTLWRLKFFV KDALDNAMKK KKEEETKTRE LSGAQKKEVS KKRNATTKLA
ERKTKRSRI
