GTE8_ARATH
ID GTE8_ARATH Reviewed; 813 AA.
AC Q9LK27; Q8W4J0;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Transcription factor GTE8;
DE AltName: Full=Bromodomain-containing protein GTE8;
DE AltName: Full=Protein GLOBAL TRANSCRIPTION FACTOR GROUP E8;
GN Name=GTE8; OrderedLocusNames=At3g27260; ORFNames=K17E12.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 523-813 (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12466527; DOI=10.1093/nar/gkf660;
RA Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S.,
RA Richards E.J., Bender J., Mount D.W., Jorgensen R.A.;
RT "Analysis of histone acetyltransferase and histone deacetylase families of
RT Arabidopsis thaliana suggests functional diversification of chromatin
RT modification among multicellular eukaryotes.";
RL Nucleic Acids Res. 30:5036-5055(2002).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9LK27-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9LK27-2; Sequence=VSP_040811, VSP_040812;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC site. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB02121.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP000381; BAB02121.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE77284.1; -; Genomic_DNA.
DR EMBL; AY062532; AAL32610.1; -; mRNA.
DR EMBL; AY093312; AAM13311.1; -; mRNA.
DR EMBL; BX824603; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_189362.1; NM_113640.2. [Q9LK27-1]
DR AlphaFoldDB; Q9LK27; -.
DR SMR; Q9LK27; -.
DR STRING; 3702.AT3G27260.1; -.
DR PaxDb; Q9LK27; -.
DR PRIDE; Q9LK27; -.
DR ProteomicsDB; 247200; -. [Q9LK27-1]
DR EnsemblPlants; AT3G27260.1; AT3G27260.1; AT3G27260. [Q9LK27-1]
DR GeneID; 822345; -.
DR Gramene; AT3G27260.1; AT3G27260.1; AT3G27260. [Q9LK27-1]
DR KEGG; ath:AT3G27260; -.
DR Araport; AT3G27260; -.
DR TAIR; locus:2086498; AT3G27260.
DR eggNOG; KOG1474; Eukaryota.
DR InParanoid; Q9LK27; -.
DR PhylomeDB; Q9LK27; -.
DR PRO; PR:Q9LK27; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LK27; baseline and differential.
DR Genevisible; Q9LK27; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd05506; Bromo_plant1; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; -; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR037377; GTE_bromo.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; SSF47370; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51525; NET; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Bromodomain; Coiled coil; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..813
FT /note="Transcription factor GTE8"
FT /id="PRO_0000406339"
FT DOMAIN 188..260
FT /note="Bromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT DOMAIN 320..402
FT /note="NET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00857"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 566..639
FT /evidence="ECO:0000255"
FT COMPBIAS 20..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 507
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q93YS6"
FT VAR_SEQ 495..503
FT /note="QSTGALEQM -> HGYLFSAKA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_040811"
FT VAR_SEQ 504..813
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_040812"
FT CONFLICT 248
FT /note="N -> D (in Ref. 3; AAL32610/AAM13311)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 813 AA; 90233 MW; 7DEF2D5B0A22F435 CRC64;
MVESAAFPGG YYRNTFEAPE ESEGSGSSAQ IDTEVTASEN SSTPARKCIM LNSNDEDPYG
VQRQVISLYN MSQSERKDLI YRLKLELEQT KIVLKNAELQ RMNPAAVSST SDRVGFSTGQ
KISSRVSNSK KPSDFAVGSG KKVRHQNGTS RGWNRGTSGK FESSKETMTS TPNITLMKQC
DTLLRKLWSH PHSWVFQAPV DVVKLNIPDY LTTIKHPMDL GTVKKNLASG VYSSPHEFAA
DVRLTFTNAM TYNPPGHDVH IMGDILSKLF EARWKTIKKK LPPCSMQTLP AVTLEPNDER
KAAISVPPAK KRKMASPVRE SVPEPVKPLM TEVERHRLGR QLESLLDELP AHIIDFLKKH
NSNGGEIAED EIEIDIDVLS DEVLVTLRNL LDEYIQNKEA KQTNVEPCEI ELINGSRPSN
SSLQRGNEMA DEYVDGNEPP ISRSSSDSDS GSSEDQSDDA KPMVQGDSSK MPETANSEAQ
RDENTRIDDL FVGSQSTGAL EQMDICSQQK LSSDESDGQH EGNILETPAS SEKRYRAALL
KNRFADIILK AREKPLPQNG IKGDPERLRK EREELVLQKK KEKARLQAEA EAAEDARRQA
EAEAAAEAAA EAKRKRELER EAARQALLKM EKTVEINENS RFLEDLEMLS SSAPEQLPSS
AEETSPERPL DALGSFNLRG SNPLEQLGLY MKQDDDEEEP EAPAVPKPDE TSTERPLDAL
GSFKLGECNP LEQLGLYMKQ DDGEEEEPEA PVVPKPNETS LERPVDAFGS FNLKGSNPLE
QLGLYMKQDD DEEEPEAPAV PNLANDVEEG EID
