ID   GTHB1_ANGJA             Reviewed;         127 AA.
AC   Q9YGK3;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Gonadotropin subunit beta-1;
DE   AltName: Full=GTH-I-beta;
DE   AltName: Full=Gonadotropin beta-I chain;
DE   Flags: Precursor;
GN   Name=cgba;
OS   Anguilla japonica (Japanese eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC   Anguilla.
OX   NCBI_TaxID=7937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=10094865; DOI=10.1006/gcen.1998.7242;
RA   Yoshiura Y., Suetake H., Aida K.;
RT   "Duality of gonadotropin in a primitive teleost, Japanese eel (Anguilla
RT   japonica).";
RL   Gen. Comp. Endocrinol. 114:121-131(1999).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; AB016169; BAA36546.1; -; mRNA.
DR   AlphaFoldDB; Q9YGK3; -.
DR   SMR; Q9YGK3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..127
FT                   /note="Gonadotropin subunit beta-1"
FT                   /id="PRO_0000011679"
FT   CARBOHYD        27
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        23..71
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..86
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..124
FT                   /evidence="ECO:0000250"
FT   DISULFID        48..102
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..104
FT                   /evidence="ECO:0000250"
FT   DISULFID        107..114
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   127 AA;  13426 MW;  A71216A62C19957B CRC64;
     MHLAVTALCL TLAPVLARAS TSCGLANISI SVENEECGGC ITFNTTACAG LCFTQDSVYK
     SSLKSYPQQA CNFRDVVYET VHLPGCPSGM DLHFTYPVAL SCECSKCNTD STDCGPLNTE
     VSGCLTH