ID   GTHB1_CARAU             Reviewed;         130 AA.
AC   Q98848;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Gonadotropin subunit beta-1;
DE   AltName: Full=Follicle-stimulating hormone-like GTH;
DE   AltName: Full=GTH-I-beta;
DE   AltName: Full=Gonadotropin beta-I chain;
DE   Flags: Precursor;
GN   Name=cgba;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=9073500; DOI=10.1006/gcen.1996.6839;
RA   Yoshiura Y., Kobayashi M., Kato Y., Aida K.;
RT   "Molecular cloning of the cDNAs encoding two gonadotropin beta subunits
RT   (GTH-I beta and -II beta) from the goldfish, Carassius auratus.";
RL   Gen. Comp. Endocrinol. 105:379-389(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9831661; DOI=10.1016/s0378-1119(98)00505-8;
RA   Sohn Y.C., Suetake H., Yoshiura Y., Kobayashi M., Aida K.;
RT   "Structural and expression analyses of gonadotropin Ibeta subunit genes in
RT   goldfish (Carassius auratus).";
RL   Gene 222:257-267(1998).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; D88023; BAA13530.1; -; mRNA.
DR   EMBL; AB015482; BAA36974.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q98848; -.
DR   SMR; Q98848; -.
DR   Ensembl; ENSCART00000122822; ENSCARP00000109802; ENSCARG00000056552.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..130
FT                   /note="Gonadotropin subunit beta-1"
FT                   /id="PRO_0000011681"
FT   CARBOHYD        30
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        26..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..89
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..105
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..107
FT                   /evidence="ECO:0000250"
FT   DISULFID        110..117
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   130 AA;  14423 MW;  0EFA7B42BEE1BCD7 CRC64;
     MRMRFVVMVI LLPALMMSGS ECRSSCRLTN ISITVESEEC GSCITIDTTA CAGLCKTQES
     VYRSPLMLSY QNTCNFREWT YETYEFKGCP ARADSIFTYP VALSCECSKC NSDITDCGVL
     SQQTLGCNAH