GTHB1_CYPCA
ID GTHB1_CYPCA Reviewed; 130 AA.
AC O13050;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Gonadotropin subunit beta-1;
DE AltName: Full=Follicle-stimulating hormone-like GTH;
DE AltName: Full=GTH-I-beta;
DE AltName: Full=Gonadotropin beta-I chain;
DE Flags: Precursor;
GN Name=cgba;
OS Cyprinus carpio (Common carp).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Cyprinus.
OX NCBI_TaxID=7962;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kobayashi M., Iwasaki M., Kondo H., Yoshiura Y., Watabe S.;
RT "cDNA cloning of cyprinid gonadotropin I beta subunits.";
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
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DR EMBL; AB003583; BAA20080.1; -; mRNA.
DR AlphaFoldDB; O13050; -.
DR SMR; O13050; -.
DR Ensembl; ENSCCRT00015002108; ENSCCRP00015001986; ENSCCRG00015001280.
DR Proteomes; UP000694384; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..130
FT /note="Gonadotropin subunit beta-1"
FT /id="PRO_0000011688"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 26..74
FT /evidence="ECO:0000250"
FT DISULFID 40..89
FT /evidence="ECO:0000250"
FT DISULFID 51..105
FT /evidence="ECO:0000250"
FT DISULFID 55..107
FT /evidence="ECO:0000250"
FT DISULFID 110..117
FT /evidence="ECO:0000250"
SQ SEQUENCE 130 AA; 14394 MW; 84258CE80651A8C8 CRC64;
MRMHFVVMVM LLPALMMAGS ECRSSCRLTN ISITVESEEC GSCITIDTTA CAGLCKTQES
VYRSPLMLSY QNTCNFREWT YETYEFKGCP ARADSVFTYP VALSCECSKC NSDITDCGAL
SQQTLSCNAH