ID   GTHB1_FUNHE             Reviewed;         114 AA.
AC   P30971;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Gonadotropin subunit beta-1;
DE   AltName: Full=GTH-I-beta;
DE   AltName: Full=Gonadotropin beta-I chain;
DE   Flags: Precursor;
GN   Name=cgba;
OS   Fundulus heteroclitus (Killifish) (Mummichog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Fundulidae; Fundulus.
OX   NCBI_TaxID=8078;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=1526312; DOI=10.1016/0303-7207(92)90132-p;
RA   Lin Y.-W.P., Rupnow B.A., Price D.A., Greenberg R.M., Wallace R.A.;
RT   "Fundulus heteroclitus gonadotropins. 3. Cloning and sequencing of
RT   gonadotropic hormone (GTH) I and II beta-subunits using the polymerase
RT   chain reaction.";
RL   Mol. Cell. Endocrinol. 85:127-139(1992).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; M87014; AAB59962.1; -; mRNA.
DR   PIR; I50553; I50553.
DR   RefSeq; NP_001296916.1; NM_001309987.1.
DR   AlphaFoldDB; P30971; -.
DR   SMR; P30971; -.
DR   Ensembl; ENSFHET00000029508; ENSFHEP00000034352; ENSFHEG00000022009.
DR   GeneID; 105930150; -.
DR   CTD; 2488; -.
DR   GeneTree; ENSGT00940000172097; -.
DR   OrthoDB; 1362225at2759; -.
DR   Proteomes; UP000265000; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..114
FT                   /note="Gonadotropin subunit beta-1"
FT                   /id="PRO_0000011691"
FT   CARBOHYD        24
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        20..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..80
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..114
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..92
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..94
FT                   /evidence="ECO:0000250"
FT   DISULFID        97..104
FT                   /evidence="ECO:0000250"
FT   VARIANT         21
FT                   /note="H -> R"
FT   VARIANT         77
FT                   /note="I -> V"
SQ   SEQUENCE   114 AA;  12599 MW;  6108173D091CDED7 CRC64;
     MQLVLMAAVL ALAEVGCFGC HLKNVSIPME RCGQRVCIHT TICEGLCFSE DAVFESPDEA
     PEHRVCNGDW SYEVKHIQGC PESITYPVAT NCYCSACNTK DTYCTRLYAH IPSC