ID   GTHB1_ICTPU             Reviewed;         132 AA.
AC   Q9DG81;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Gonadotropin subunit beta-1;
DE   AltName: Full=GTH beta-1;
DE   AltName: Full=GTH-I-beta;
DE   AltName: Full=Gonadotropin beta-I chain;
DE   Flags: Precursor;
GN   Name=cgba;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Kansas;
RA   Liu Z.J., Kim S., Karsi A., Dunham R.;
RT   "Channel catfish gonadotropin beta-subunits: cDNA cloning and their
RT   expression during ovulation.";
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; AF112191; AAG32155.1; -; mRNA.
DR   RefSeq; NP_001187008.1; NM_001200079.1.
DR   AlphaFoldDB; Q9DG81; -.
DR   SMR; Q9DG81; -.
DR   STRING; 7998.ENSIPUP00000027043; -.
DR   GeneID; 100304480; -.
DR   KEGG; ipu:100304480; -.
DR   CTD; 2488; -.
DR   OrthoDB; 1362225at2759; -.
DR   Proteomes; UP000221080; Chromosome 27.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016913; F:follicle-stimulating hormone activity; IDA:AgBase.
DR   GO; GO:0031762; F:follicle-stimulating hormone receptor binding; IDA:AgBase.
DR   GO; GO:2000836; P:positive regulation of androgen secretion; IMP:AgBase.
DR   GO; GO:2000866; P:positive regulation of estradiol secretion; IDA:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..132
FT                   /note="Gonadotropin subunit beta-1"
FT                   /id="PRO_0000011695"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        25..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..88
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..104
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..106
FT                   /evidence="ECO:0000250"
FT   DISULFID        109..116
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   132 AA;  14560 MW;  9BAEB9D425B54038 CRC64;
     MMRGVTMVLL LPMLVWAGSE CKARCCLTNI SITVESDECG SCITVNTTAC TGLCRTQERA
     YRSPVAPYFQ NTCNFRDWTY ETIQLPGCPL GVDSSFTYPV ALSCECSQCN TEITDCGAFS
     MQPSSCHTHA YY