ID   GTHB1_THUOB             Reviewed;         102 AA.
AC   P37205;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Gonadotropin subunit beta-1;
DE   AltName: Full=GTH-I-beta;
DE   AltName: Full=Gonadotropin beta-I chain;
GN   Name=cgba;
OS   Thunnus obesus (Bigeye tuna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Pelagiaria; Scombriformes; Scombridae; Thunnus.
OX   NCBI_TaxID=8241;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pituitary;
RX   PubMed=8138353; DOI=10.1111/j.1399-3011.1994.tb00377.x;
RA   Okada T., Kawazoe I., Kimura S., Sasamoto Y., Aida K., Kawauchi H.;
RT   "Purification and characterization of gonadotropin I and II from pituitary
RT   glands of tuna (Thunnus obesus).";
RL   Int. J. Pept. Protein Res. 43:69-80(1994).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P37205; -.
DR   SMR; P37205; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone; Secreted.
FT   CHAIN           1..102
FT                   /note="Gonadotropin subunit beta-1"
FT                   /id="PRO_0000149036"
FT   CARBOHYD        12
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   DISULFID        8..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        20..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..77
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..79
FT                   /evidence="ECO:0000250"
FT   DISULFID        82..89
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   102 AA;  11112 MW;  81934055D8AF99B2 CRC64;
     GQGCSYGCHP KNISISVESC GITEFILTTI CEGQCYLEDP VYISHDEQKI CNGDWSYEVK
     HIEGCPVGVT YPVARNCECT ACNTGNTYCG RLPGYVPSCP SF