ID   GTHB2_ANGAN             Reviewed;         140 AA.
AC   P27767;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Gonadotropin subunit beta-2;
DE   AltName: Full=GTH-II-beta;
DE   AltName: Full=Gonadotropin beta-II chain;
DE   Flags: Precursor;
GN   Name=cgbb;
OS   Anguilla anguilla (European freshwater eel) (Muraena anguilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC   Anguilla.
OX   NCBI_TaxID=7936;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=2116136; DOI=10.1677/jme.0.0040257;
RA   Querat B., Moumni M., Jutisz M., Fontaine Y.-A., Counis R.;
RT   "Molecular cloning and sequence analysis of the cDNA for the putative beta
RT   subunit of the type-II gonadotrophin from the European eel.";
RL   J. Mol. Endocrinol. 4:257-264(1990).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X61039; CAA43374.1; -; mRNA.
DR   PIR; A48166; A48166.
DR   AlphaFoldDB; P27767; -.
DR   SMR; P27767; -.
DR   OMA; CTYRDFY; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..140
FT                   /note="Gonadotropin subunit beta-2"
FT                   /id="PRO_0000011680"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        30..78
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..93
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..131
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..109
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..111
FT                   /evidence="ECO:0000250"
FT   DISULFID        114..121
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   140 AA;  15478 MW;  10312C061717DD80 CRC64;
     MSVYPECTWL LFVCLCHLLV SAGGSLLLPC EPINETISVE KDGCPKCLVF QTSICSGHCI
     TKDPSYKSPL STVYQRVCTY RDVRYETVRL PDCRPGVDPH VTFPVALSCD CNLCTMDTSD
     CAIQSLRPDF CMSQRASLPA