ID   GTHB2_CARAU             Reviewed;         140 AA.
AC   Q98849;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Gonadotropin subunit beta-2;
DE   AltName: Full=GTH-II-beta;
DE   AltName: Full=Gonadotropin beta-II chain;
DE   AltName: Full=Luteinizing hormone-like GTH;
DE   Flags: Precursor;
GN   Name=cgbb;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=9073500; DOI=10.1006/gcen.1996.6839;
RA   Yoshiura Y., Kobayashi M., Kato Y., Aida K.;
RT   "Molecular cloning of the cDNAs encoding two gonadotropin beta subunits
RT   (GTH-I beta and -II beta) from the goldfish, Carassius auratus.";
RL   Gen. Comp. Endocrinol. 105:379-389(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Sohn Y.C., Yoshiura Y., Suetake H., Kobayashi M., Aida K.;
RT   "Nucleotide sequence of gonadotropin II beta subunit gene in goldfish.";
RL   Fish. Sci. 65:800-801(1999).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; D88024; BAA13531.1; -; mRNA.
DR   EMBL; AB015596; BAA86658.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q98849; -.
DR   SMR; Q98849; -.
DR   Ensembl; ENSCART00000069435; ENSCARP00000065403; ENSCARG00000029257.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..140
FT                   /note="Gonadotropin subunit beta-2"
FT                   /id="PRO_0000011682"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        29..77
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..92
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..130
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..110
FT                   /evidence="ECO:0000250"
FT   DISULFID        113..120
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   140 AA;  15533 MW;  1BE663562979ADFA CRC64;
     MGTPVKILVV LFSVIVLLAV AQSSYLPPCE PVNETVAVEK EGCPKCLVLQ TTICSGHCLT
     KEPVYKSPFS TVYQHVCTYR DVRYETVRLP DCPPGVDPHI TYPVALSCDC SLCTMDTSDC
     TIESLQPDFC MSQREDFLVY