ID   GTHB2_CTEID             Reviewed;         146 AA.
AC   P30984;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Gonadotropin subunit beta-2;
DE   AltName: Full=GTH-II-beta;
DE   AltName: Full=Gonadotropin beta-II chain;
DE   AltName: Full=Luteinizing hormone-like GTH;
DE   Flags: Precursor; Fragment;
GN   Name=cgbb;
OS   Ctenopharyngodon idella (Grass carp) (Leuciscus idella).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Xenocyprididae; Xenocypridinae; Ctenopharyngodon.
OX   NCBI_TaxID=7959;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RA   Chang Y.S., Huang F.-L., Lo T.-B.;
RT   "The cDNA cloning and primary structures of grass carp gonadotropin
RT   subunits.";
RL   Submitted (JUL-1991) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; X61051; CAA43385.1; -; mRNA.
DR   PIR; S16763; S16763.
DR   AlphaFoldDB; P30984; -.
DR   SMR; P30984; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031762; F:follicle-stimulating hormone receptor binding; ISS:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0031775; F:lutropin-choriogonadotropic hormone receptor binding; ISS:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR   GO; GO:2000836; P:positive regulation of androgen secretion; ISS:UniProtKB.
DR   GO; GO:2000866; P:positive regulation of estradiol secretion; ISS:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          <1..28
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..146
FT                   /note="Gonadotropin subunit beta-2"
FT                   /id="PRO_0000011687"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        35..83
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..98
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..136
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..114
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..116
FT                   /evidence="ECO:0000250"
FT   DISULFID        119..126
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   146 AA;  16320 MW;  691734444C679082 CRC64;
     TGTPVKILVV RNILLLLFCL VVLLVFAQSS FLPPCEPVNE TVAVEKEGCP KCLVFQTTIC
     SGHCLTKEPV YKSPFSTVYQ HVCTYRDVRY ETVRLPDCPP GVDPHITYPV ALSCDCSLCT
     MDTSDCTIES LQPDFCMSQR EDFPVY