ID   GTHB2_CYPCA             Reviewed;         144 AA.
AC   P01235;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Gonadotropin subunit beta-2;
DE   AltName: Full=GTH-II-beta;
DE   AltName: Full=Gonadotropin beta-II chain;
DE   AltName: Full=Luteinizing hormone-like GTH;
DE   Flags: Precursor;
GN   Name=cgbb;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3246480; DOI=10.1111/j.1399-3011.1988.tb01387.x;
RA   Chang Y.S., Huang C.-J., Huang F.-L., Lo T.-B.;
RT   "Primary structures of carp gonadotropin subunits deduced from cDNA
RT   nucleotide sequences.";
RL   Int. J. Pept. Protein Res. 32:556-564(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Chang Y.S., Huang F.-L., Lo T.-B.;
RL   Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 28-53 AND 141-142.
RX   PubMed=607993; DOI=10.1016/s0300-9084(78)80704-4;
RA   Jolles J., Burzawa-Gerard E., Fontaine Y.-A., Jolles P.;
RT   "The evolution of gonadotropins: some molecular data concerning a non-
RT   mammalian pituitary gonadotropin, the hormone from a teleost fish (Cyprinus
RT   carpio L.).";
RL   Biochimie 59:893-898(1977).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; X59888; CAA42542.1; -; Genomic_DNA.
DR   EMBL; X59889; CAA42543.1; -; Genomic_DNA.
DR   PIR; S29677; UTCAB.
DR   RefSeq; XP_018952841.1; XM_019097296.1.
DR   AlphaFoldDB; P01235; -.
DR   SMR; P01235; -.
DR   Ensembl; ENSCCRT00000101317; ENSCCRP00000093311; ENSCCRG00000050461.
DR   Ensembl; ENSCCRT00010065555; ENSCCRP00010059780; ENSCCRG00010025333.
DR   Ensembl; ENSCCRT00015095018; ENSCCRP00015092063; ENSCCRG00015037106.
DR   Ensembl; ENSCCRT00020062409; ENSCCRP00020056601; ENSCCRG00020026882.
DR   GeneID; 109082413; -.
DR   KEGG; ccar:109082413; -.
DR   CTD; 3972; -.
DR   GeneTree; ENSGT00940000161285; -.
DR   OrthoDB; 1362225at2759; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031762; F:follicle-stimulating hormone receptor binding; ISS:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0031775; F:lutropin-choriogonadotropic hormone receptor binding; ISS:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR   GO; GO:2000836; P:positive regulation of androgen secretion; ISS:UniProtKB.
DR   GO; GO:2000866; P:positive regulation of estradiol secretion; ISS:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000269|PubMed:607993"
FT   CHAIN           28..142
FT                   /note="Gonadotropin subunit beta-2"
FT                   /id="PRO_0000011689"
FT   PROPEP          143..144
FT                   /id="PRO_0000011690"
FT   CARBOHYD        37
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   DISULFID        33..81
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..96
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..134
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..112
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..114
FT                   /evidence="ECO:0000250"
FT   DISULFID        117..124
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   144 AA;  16040 MW;  854FE80D4A39DCF8 CRC64;
     MGTPVKILVV RNHILFSVVV LLAVAQSSYL PPCEPVNETV AVEKEGCPKC LVLQTTICSG
     HCLTKEPVYK SPFSTVYQHV CTYRDVRYET VRLPDCPPGV DPHITYPVAL SCDCSLCTMD
     TSDCTIESLQ PDFCMSQRED FLVY