ID   GTHB2_FUNHE             Reviewed;         136 AA.
AC   P30972;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Gonadotropin subunit beta-2;
DE   AltName: Full=GTH-II-beta;
DE   AltName: Full=Gonadotropin beta-II chain;
DE   Flags: Precursor;
GN   Name=cgbb;
OS   Fundulus heteroclitus (Killifish) (Mummichog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Fundulidae; Fundulus.
OX   NCBI_TaxID=8078;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=1526312; DOI=10.1016/0303-7207(92)90132-p;
RA   Lin Y.-W.P., Rupnow B.A., Price D.A., Greenberg R.M., Wallace R.A.;
RT   "Fundulus heteroclitus gonadotropins. 3. Cloning and sequencing of
RT   gonadotropic hormone (GTH) I and II beta-subunits using the polymerase
RT   chain reaction.";
RL   Mol. Cell. Endocrinol. 85:127-139(1992).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; M87015; AAB59963.1; -; mRNA.
DR   PIR; I50554; I50554.
DR   RefSeq; NP_001296857.1; NM_001309928.1.
DR   AlphaFoldDB; P30972; -.
DR   SMR; P30972; -.
DR   STRING; 8078.ENSFHEP00000010305; -.
DR   GeneID; 105933358; -.
DR   CTD; 3972; -.
DR   Proteomes; UP000265000; Whole Genome Shotgun Assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..136
FT                   /note="Gonadotropin subunit beta-2"
FT                   /id="PRO_0000011692"
FT   CARBOHYD        31
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        27..75
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..90
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..128
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..106
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        111..118
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   136 AA;  15016 MW;  716576844A6A1653 CRC64;
     MVCLFLGASS FIWSLAPAAA AFQLPRCQLL NQTISLEKRG CSGCHRVETT ICSGYCATKD
     PNYKTSYNKA IQHVCTYGDL YYKTFEFPEC VPGVDPVVTY PVALSCRCGG CAMATSDCTF
     ESLQPDFCMN DIPFYH