ID   GTHB2_HYPMO             Reviewed;         141 AA.
AC   P37038;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Gonadotropin subunit beta-2;
DE   AltName: Full=GTH-II-beta;
DE   AltName: Full=Gonadotropin beta-II chain;
DE   AltName: Full=Luteinizing hormone-like GTH;
DE   Flags: Precursor;
GN   Name=cgbb;
OS   Hypophthalmichthys molitrix (Silver carp) (Leuciscus molitrix).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Xenocyprididae; Xenocypridinae; Hypophthalmichthys.
OX   NCBI_TaxID=13095;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Pituitary;
RX   PubMed=2332148; DOI=10.1016/0016-6480(90)90043-l;
RA   Chang Y.S., Huang C.J., Huang F.-L., Liu C.S., Lo T.-B.;
RT   "Purification, characterization, and molecular cloning of gonadotropin
RT   subunits of silver carp (Hypophthalmichthys molitrix).";
RL   Gen. Comp. Endocrinol. 78:23-33(1990).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   PIR; B60626; B60626.
DR   AlphaFoldDB; P37038; -.
DR   SMR; P37038; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT   CHAIN           25..139
FT                   /note="Gonadotropin subunit beta-2"
FT                   /id="PRO_0000011693"
FT   PROPEP          140..141
FT                   /id="PRO_0000011694"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        30..78
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..93
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..131
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..109
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..111
FT                   /evidence="ECO:0000250"
FT   DISULFID        114..121
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   141 AA;  15856 MW;  A42C48FE983EEA46 CRC64;
     MLAVRNNILL LLFCLVVLLV FAQSSFLPPC EPVNETVAVE KEGCPKCLVF QTTICSGHCL
     TKEPVYKSPF STVYQHVCTY RDVRYETVRL PDCPPGVDPH ITYPVALSCD CSLCTMDTSD
     CTIESLQPDY CMSQREDFPV Y