ID   GTHB2_ICTPU             Reviewed;         140 AA.
AC   Q9DG80;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Gonadotropin subunit beta-2;
DE   AltName: Full=GTH-II-beta;
DE   AltName: Full=Gonadotropin beta-II chain;
DE   AltName: Full=GtH beta-2;
DE   Flags: Precursor;
GN   Name=cgbb;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Kansas;
RA   Liu Z.J., Kim S., Karsi A., Dunham R.;
RT   "Channel catfish gonadotropin beta-subunits: cDNA cloning and their
RT   expression during ovulation.";
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; AF112192; AAG32156.1; -; mRNA.
DR   RefSeq; NP_001187009.1; NM_001200080.1.
DR   AlphaFoldDB; Q9DG80; -.
DR   SMR; Q9DG80; -.
DR   STRING; 7998.ENSIPUP00000022977; -.
DR   GeneID; 100304481; -.
DR   KEGG; ipu:100304481; -.
DR   CTD; 3972; -.
DR   Proteomes; UP000221080; Chromosome 3.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031762; F:follicle-stimulating hormone receptor binding; IDA:AgBase.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0031775; F:lutropin-choriogonadotropic hormone receptor binding; IDA:AgBase.
DR   GO; GO:0046982; F:protein heterodimerization activity; IPI:AgBase.
DR   GO; GO:2000836; P:positive regulation of androgen secretion; IMP:AgBase.
DR   GO; GO:2000866; P:positive regulation of estradiol secretion; IDA:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..140
FT                   /note="Gonadotropin subunit beta-2"
FT                   /id="PRO_0000011696"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        29..77
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..92
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..130
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..110
FT                   /evidence="ECO:0000250"
FT   DISULFID        113..120
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   140 AA;  15787 MW;  AAA74CAA7E3D2882 CRC64;
     MSVPASSFLL LCFLMNSFSP AQSYILPHCE PVNETVSVEK DGCPKCLVFQ TAICSGHCLT
     KEPVYKSPFS NIYQHVCTYR DVRYETVRLP DCRPGVDPHV TYPVALSCEC TLCTMDTSDC
     TIESLNPDFC MTQKEYILDY