ID   GTHB2_MORSA             Reviewed;         139 AA.
AC   Q91121;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Gonadotropin subunit beta-2;
DE   AltName: Full=GTH-II-beta;
DE   AltName: Full=Gonadotropin beta-II chain;
DE   Flags: Precursor;
GN   Name=cgbb;
OS   Morone saxatilis (Striped bass) (Perca saxatilis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Moronidae; Morone.
OX   NCBI_TaxID=34816;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=8546811; DOI=10.1677/jme.0.0150023;
RA   Hassin S., Elizur A., Zohar Y.;
RT   "Molecular cloning and sequence analysis of striped bass (Morone saxatilis)
RT   gonadotrophin-I and -II subunits.";
RL   J. Mol. Endocrinol. 15:23-35(1995).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC38019.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L35096; AAC38019.1; ALT_INIT; mRNA.
DR   PIR; I50994; I50994.
DR   AlphaFoldDB; Q91121; -.
DR   SMR; Q91121; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..139
FT                   /note="Gonadotropin subunit beta-2"
FT                   /id="PRO_0000011698"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        30..78
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..93
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..131
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..109
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..111
FT                   /evidence="ECO:0000250"
FT   DISULFID        114..121
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   139 AA;  15555 MW;  1AB8B742FD81AF76 CRC64;
     MFPLVLSLFL GATSDIWPLA PAEAFQLPPC QLINQTVSLE KEGCPKCHPV ETTICSGHCI
     TKDPVIKIPF SNVYQHVCTY RDLHYKTFEL PDCPPGVDPT VTYPVAQSCH CGRCAMDTSD
     CTFESLQPNF CMNDIPFYY