ID   GTHB2_ONCKE             Reviewed;         142 AA.
AC   P10256;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Gonadotropin subunit beta-2;
DE   AltName: Full=GTH-II-beta;
DE   AltName: Full=Gonadotropin beta-II chain;
DE   Flags: Precursor;
GN   Name=cgbb;
OS   Oncorhynchus keta (Chum salmon) (Salmo keta).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8018;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2813416; DOI=10.1073/pnas.86.22.8645;
RA   Sekine S., Saito A., Itoh H., Kawauchi H., Itoh S.;
RT   "Molecular cloning and sequence analysis of chum salmon gonadotropin
RT   cDNAs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:8645-8649(1989).
RN   [2]
RP   PROTEIN SEQUENCE OF 24-142.
RX   PubMed=3192067; DOI=10.1016/0016-6480(88)90273-0;
RA   Itoh H., Suzuki K., Kawauchi H.;
RT   "The complete amino acid sequences of beta-subunits of two distinct chum
RT   salmon GTHs.";
RL   Gen. Comp. Endocrinol. 71:438-451(1988).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; M27154; AAA49409.1; -; mRNA.
DR   PIR; C36179; C36179.
DR   AlphaFoldDB; P10256; -.
DR   SMR; P10256; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:3192067"
FT   CHAIN           24..142
FT                   /note="Gonadotropin subunit beta-2"
FT                   /id="PRO_0000011700"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   DISULFID        29..77
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..92
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..130
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..110
FT                   /evidence="ECO:0000250"
FT   DISULFID        113..120
FT                   /evidence="ECO:0000250"
FT   VARIANT         73
FT                   /note="Y -> I"
FT   VARIANT         86
FT                   /note="T -> K"
SQ   SEQUENCE   142 AA;  15872 MW;  E31E117DA235C486 CRC64;
     MLGLHVGTLI SLFLCILLEP VEGSLMQPCQ PINQTVSLEK EGCPTCLVIQ TPICSGHCVT
     KEPVFKSPFS TVYQHVCTYR DVRYETIRLP DCPPWVDPHV TYPVALSCDC SLCNMDTSDC
     TIESLQPDFC ITQRVLTDGD MW